Abstract | AIM: To investigate the associations of blood pressure variability (BPV), expressed as long-term (visit-to-visit) and short-term (ambulatory blood pressure monitoring [ABPM] and home blood pressure monitoring [ HBPM]) and all-cause mortality, major adverse cardiovascular events (MACEs), extended MACEs, microvascular complications (MiCs) and hypertension-mediated organ damage (HMOD) in adult patients with type 2 diabetes. MATERIALS AND METHODS: PubMed, Medline, Embase, Cinahl, Web of Science, ClinicalTrials.gov and grey literature databases were searched for studies including patients with type 2 diabetes, at least one variable of BPV (visit-to-visit, HBPM, ABPM) and evaluation of the incidence of at least one of the following outcomes: all-cause mortality, MACEs, extended MACEs and/or MiCs and/or HMOD. The extracted information was analyzed using random effects meta-analysis and meta-regression. RESULTS: Data from a total of 377 305 patients were analyzed. Systolic blood pressure (SBP) variability was associated with a significantly increased risk of all-cause mortality (HR 1.12, 95% CI 1.04-1.21), MACEs (HR 1.01, 95% CI 1.04-1.17), extended MACEs (HR 1.07, 95% CI 1.03-1.11) and MiCs (HR 1. 12, 95% CI 1.01-1.24), while diastolic blood pressure was not. Associations were mainly driven from studies on long-term SBP variability. Qualitative analysis showed that BPV was associated with the presence of HMOD expressed as carotid intima-media thickness, pulse wave velocity and left ventricular hypertrophy. Results were independent of mean blood pressure, glycaemic control and serum creatinine levels. CONCLUSIONS:
|
Authors | Martina Chiriacò, Konstantinos Pateras, Agostino Virdis, Marietta Charakida, Despoina Kyriakopoulou, Monica Nannipieri, Michele Emdin, Konstantinos Tsioufis, Stefano Taddei, Stefano Masi, Georgios Georgiopoulos |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 21
Issue 12
Pg. 2587-2598
(12 2019)
ISSN: 1463-1326 [Electronic] England |
PMID | 31282073
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
|
Copyright | © 2019 John Wiley & Sons Ltd. |
Topics |
- Adult
- Blood Pressure
(physiology)
- Cardiovascular Diseases
(complications, mortality)
- Diabetes Mellitus, Type 2
(complications, epidemiology, physiopathology)
- Female
- Humans
- Male
|