Abstract | PURPOSE: METHODS: We identified patients initially suspected with axillary disease who achieved ypN0 following NAC. From 13 institutions of the Korean Radiation Oncology Group between 2005 and 2011, a total of 189 patients were included in the analysis. Effects of PMRT on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) were evaluated for different molecular subtypes. RESULTS: In all patients, the prognostic effect of PMRT on LRC, DFS, or OS was not significant. Subgroups analysis showed that the effect of PMRT on LRC was different according to molecular subtype (p for interaction = 0.019). PMRT was associated with greater LRC in the luminal subtype (p = 0.046), but not in other subtypes. CONCLUSION: In patients who achieve ypN0 following NAC and mastectomy, PMRT shows no additional survival benefits for any molecular subtype.
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Authors | Won Kyung Cho, Won Park, Doo Ho Choi, Yong Bae Kim, Jin Ho Kim, Su Ssan Kim, Kyubo Kim, Jin Hee Kim, Sung-Ja Ahn, Sun Young Lee, Jeongshim Lee, Sang-Won Kim, Jeanny Kwon, Ki Jung Ahn |
Journal | Journal of breast cancer
(J Breast Cancer)
Vol. 22
Issue 2
Pg. 285-296
(06 2019)
ISSN: 1738-6756 [Print] Korea (South) |
PMID | 31281730
(Publication Type: Journal Article)
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