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Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.

Abstract
Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification controls macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor.
AuthorsPei Sun, Shu-Jing Zhang, Semenov Maksim, Yong-Fang Yao, Hong-Min Liu, Juan Du
JournalCurrent topics in medicinal chemistry (Curr Top Med Chem) Vol. 19 Issue 15 Pg. 1350-1362 ( 2019) ISSN: 1873-4294 [Electronic] United Arab Emirates
PMID31215380 (Publication Type: Journal Article, Review)
CopyrightCopyright© Bentham Science Publishers; For any queries, please email at [email protected].
Chemical References
  • Antineoplastic Agents
  • Histones
Topics
  • Acetylation (drug effects)
  • Animals
  • Antineoplastic Agents (chemistry, pharmacology)
  • DNA Methylation (drug effects)
  • Epigenesis, Genetic (drug effects, genetics)
  • Histones (drug effects, metabolism)
  • Humans
  • Inflammation (drug therapy, metabolism, pathology)
  • Macrophages (drug effects, metabolism, pathology)
  • Methylation (drug effects)
  • Neoplasms (drug therapy, metabolism, pathology)

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