[Clinical value of serum neuroglobin in evaluating hypoglycemic brain injury in neonates].

Abstract

OBJECTIVE:

To study the clinical value of serum neuroglobin in evaluating hypoglycemic brain injury in neonates.

METHODS:

A total of 100 neonates with hypoglycemia were enrolled as subjects. According to amplitude-integrated EEG (aEEG) findings and/or clinical manifestations, they were divided into symptomatic hypoglycemic brain injury group (n=22), asymptomatic hypoglycemic brain injury group (n=37) and hypoglycemic non-brain injury group (n=41). The three groups were compared in terms of blood glucose, duration of hypoglycemia, levels of neuroglobin and neuron-specific enolase (NSE), and modified aEEG score. The correlation of neuroglobin with NSE and modified aEEG score was analyzed. The receiver operating characteristic (ROC) curve was plotted.

RESULTS:

Compared with the asymptomatic hypoglycemic brain injury and hypoglycemic non-brain injury groups, the symptomatic hypoglycemic brain injury group had significantly lower blood glucose and modified aEEG score, significantly higher neuroglobin and NSE levels, and a significantly longer duration of hypoglycemia (P<0.05). Compared with the hypoglycemic non-brain injury group, the asymptomatic hypoglycemic brain injury group had significantly lower blood glucose and modified aEEG score, significantly higher neuroglobin and NSE levels, and a significantly longer duration of hypoglycemia (P<0.05). Neuroglobin was positively correlated with NSE and duration of hypoglycemia (r=0.922 and 0.929 respectively; P<0.05) and negatively correlated with blood glucose and modified aEEG score (r=-0.849 and -0.968 respectively; P<0.05). The areas under the ROC curve of neuroglobin, NSE and modified aEEG score were 0.894, 0.890 and 0.941 respectively, and neuroglobin had a sensitivity of 80.8% and a specificity of 95.8% at the optimal cut-off value of 108 mg/L.

CONCLUSIONS:

Like NSE and modified aEEG score, serum neuroglobin can also be used as a specific indicator for the assessment of brain injury in neonates with hypoglycemia and has a certain value in clinical practice.

• Authors: Feng-Yuan Jiang, Hui-Ping Liu, Li-Ting Chen, Zhong-Rui Song, Shang Xu, Yu-Xiu Guo, Lin Zhou, Yu-Kun Wang, Gui-Hua Shu
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 21 Issue 6 Pg. 573-579 (Jun 2019) ISSN: 1008-8830 [Print] China
• PMID: 31208512 (Publication Type: Journal Article)

Chemical References

• Hypoglycemic Agents
• Neuroglobin
• Phosphopyruvate Hydratase

Topics

• Brain Injuries
• Electroencephalography
• Humans
• Hypoglycemic Agents
• Infant, Newborn
• Neuroglobin (blood)
• Phosphopyruvate Hydratase