Abstract | BACKGROUND: SUMMARY: We hereby present 3 cases of anti-MOG+ patients with different disease courses - ranging from mild to severe - all presenting with Optic neuritis (ON) at the onset. Optic neuritis (ON) is a common manifestation of different central nervous system (CNS) inflammatory disorders and can represent the first clinical event of MS and NMOSD. ON is also the most common presentation of antiMOG demyelinating disorders, followed by - and sometimes associated with - myelitis, most commonly extended over more than 2 spinal cord segments and defined as longitudinally extended transverse myelitis (LETM). All the three patients tested negative for oligoclonal bands in CSF and anti-AQP4 Ab in serum, had a relapsing disease course characterized by prominent involvement of the optic nerve and spinal cord, with good recovery after treatment with high-dose corticosteroids. However, they had a different disease course at follow-up and underwent different treatment approaches. CONCLUSIONS: Since anti-MOG+ patients can have a multiphasic disease course and accumulate disability over time, a high degree of suspicion and early diagnosis are of critical importance for treatment decision-making in clinical practice. AIM: The aim of this case report is to enhance focus on an emerging disease spectrum among acquired CNS demyelinating disorders.
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Authors | A Bellinvia, L Pastò, L Razzolini, R Fratangelo, E Prestipino, M Fonderico, L Tudisco, M P Amato |
Journal | Multiple sclerosis and related disorders
(Mult Scler Relat Disord)
Vol. 33
Pg. 51-54
(Aug 2019)
ISSN: 2211-0356 [Electronic] Netherlands |
PMID | 31152967
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Autoantibodies
- Autoantigens
- MOG protein, human
- Myelin-Oligodendrocyte Glycoprotein
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Topics |
- Adolescent
- Adult
- Autoantibodies
(immunology)
- Autoantigens
(immunology)
- Demyelinating Autoimmune Diseases, CNS
(immunology, pathology)
- Female
- Humans
- Myelin-Oligodendrocyte Glycoprotein
(immunology)
- Optic Neuritis
(immunology)
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