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A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression.

Abstract
Little is known about how Treg cells mediate suppression, especially in tissues. In this issue of Immunity, Schmidleithner et al. report that Treg cells catabolize PGE2 into 15-keto-PGE2, a T cell-inhibitory metabolite, and that this mechanism controls inflammation in adipose tissue.
AuthorsDan Wu, Megan K Levings
JournalImmunity (Immunity) Vol. 50 Issue 5 Pg. 1122-1124 (05 21 2019) ISSN: 1097-4180 [Electronic] United States
PMID31117006 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
Topics
  • Adipose Tissue
  • Animals
  • Homeostasis
  • Humans
  • Inflammation
  • Mice
  • T-Lymphocytes, Regulatory

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