RESULTS: Median serum sTREM-1 concentrations were higher in
severe sepsis (540 pg/ml) and
septic shock (536 pg/ml) in comparison with NI-SIRS patients (p < 0.05). There were no differences in sTREM-1 levels between NI-SIRS and
sepsis. Similarly, CRP, PCT and
IL-6 were significantly elevated in patients with
severe sepsis and
septic shock in comparison with NI-SIRS. The receiver operating characteristic curve analysis for diagnosis of
severe sepsis showed higher discriminative value for CRP and
IL-6 (AUC = 0.909, 95% CI: 0.829-0.99 and AUC = 0.854, 95% CI: 0.728-0.980, respectively) than sTREM-1 (AUC = 0.733, 95% CI: 0.596-0.870). In
septic shock the highest AUC was found for CRP (AUC = 0.938, 95% CI: 0.872-1.0), lower for
IL-6 (AUC = 0.869, 95% CI: 0.751-0.987), PCT (AUC = 0.828, 95% CI: 0.71-0.945) and sTREM-1 (AUC = 0.705, 95% CI: 0.553-0.856).
CONCLUSIONS: