Abstract | PURPOSE: The purpose of this study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing the postoperative hypothalamic-pituitary-adrenal (HPA) axis function after pituitary tumor surgery. METHODS: RESULTS: ROC analysis showed a cut-off of the basal cortisol level of ≥300 nmol/L measured on the second postoperative day to predict normal postoperative HPA axis function with the sensitivity of 92.31%, specificity of 87.14% and positive predictive value of 57.14%. CONCLUSION: The basal cortisol level on the second postoperative day is a valuable tool to predict integrity of the HPA axis after pituitary tumor surgery. Our data suggest that the cortisol level of ≥300 nmol/L accurately predicts adrenal sufficiency and that in these patients glucocorticoid therapy can be withdrawn.
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Authors | Tanja Skoric Polovina, Ivana Kraljevic, Mirsala Solak, Annemarie Balasko, Arta Haxhiu, Arita Haxhiu, Tina Dusek, Tamara Poljicanin, Darko Kastelan |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 128
Issue 11
Pg. 709-714
(Nov 2020)
ISSN: 1439-3646 [Electronic] Germany |
PMID | 31091548
(Publication Type: Journal Article, Observational Study)
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Copyright | Thieme. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Female
- Follow-Up Studies
- Humans
- Hydrocortisone
(blood)
- Hypothalamo-Hypophyseal System
(physiopathology)
- Male
- Middle Aged
- Pituitary Neoplasms
(surgery)
- Postoperative Period
- Prognosis
- Prospective Studies
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