Crosstalk between Oxidative Stress and Tauopathy.

Abstract

Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients' brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy.

• Authors: Md Mamunul Haque, Dhiraj P Murale, Yun Kyung Kim, Jun-Seok Lee
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 8 (Apr 22 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 31013607 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants
• Protein Aggregates
• Reactive Oxygen Species
• tau Proteins

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Humans
• Oxidation-Reduction
• Oxidative Stress
• Protein Aggregates
• Protein Aggregation, Pathological (metabolism)
• Protein Binding
• Reactive Oxygen Species (metabolism)
• Signal Transduction
• Tauopathies (drug therapy, etiology, metabolism, pathology)
• tau Proteins (genetics, metabolism)