Abstract | BACKGROUND: METHODS: RESULTS: The 65 patients (median age = 51 years, male:female = 34:31) enrolled in this study had diagnoses of AML (33, 50.8%), acute lymphoblastic leukemia (31, 47.7%), and acute biphenotypic leukemia (1, 1.5%). Median duration of micafungin treatment was 24 days (range 1-68), with proven invasive fungal disease in one patient (1.5%) and possible fungal infection in two patients (3.1%). Three of the patients (4.6%) experienced the following adverse events, but all events were tolerable: liver function abnormality (Grade 2, n = 1; Grade 3, n = 1) and allergic reaction (Grade 2, n = 1). Three patients died during induction therapy, and invasive aspergillosis pneumonia was the cause of death for one of those patients. Overall, 19 patients (29.2%) discontinued prophylactic micafungin, and 18 (27.7%) patients switched to another antifungal agent. We observed no fungal infections caused by amphotericin B-resistant organisms. In AML patients, outcomes of prophylactic micafungin during induction chemotherapy did not differ significantly with those of prophylactic posaconazole with regard to incidence of fungal infections, rate of discontinuation, or safety. CONCLUSIONS: TRIAL REGISTRATION: Clinicaltrials.gov NCT02440178, registered May 12th 2015.
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Authors | Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park, Youngil Koh |
Journal | BMC cancer
(BMC Cancer)
Vol. 19
Issue 1
Pg. 358
(Apr 16 2019)
ISSN: 1471-2407 [Electronic] England |
PMID | 30991992
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Micafungin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(therapeutic use)
- Female
- Humans
- Induction Chemotherapy
(adverse effects, methods)
- Kaplan-Meier Estimate
- Leukemia, Myeloid, Acute
(complications, drug therapy, mortality)
- Male
- Micafungin
(therapeutic use)
- Middle Aged
- Mycoses
(diagnosis, etiology, prevention & control)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, drug therapy, mortality)
- Prognosis
- Treatment Outcome
- Young Adult
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