Abstract | BACKGROUND:
Hydroxychloroquine (HCQ) is regarded as a mainstay in the treatment of systemic lupus erythematosus (SLE) because of its efficacy in preventing flares, achieving remission, and reducing overall mortality. However, the impact of HCQ on pregnancy outcomes remains controversial. OBJECTIVE: We aimed to investigate the effect of HCQ on pregnancy outcomes in patients with SLE. METHODS: RESULTS:
Preeclampsia was significantly less complicated (7.5% vs 19.7%, p = 0.032) and neonatal birth weight was significantly greater (2757.0 ± 583.5 g vs 2542.3 ± 908.3 g, p = 0.001) in the HCQ treatment group than in the HCQ nontreatment group. Multiple logistic analysis adjusting for body mass index (BMI), lupus nephritis, serum uric acid, and estimated glomerular filtration rate revealed HCQ treatment was associated with exceedingly lower risk of preeclampsia in SLE pregnancy (odds ratio (OR) 0.106 (confidence interval (CI) 0.017-0.671)). Other independent risk factors for preeclampsia were a high prepregnancy BMI (OR 1.575 (CI 1.114-2.227)) and low eGFR level (OR 0.931 (CI 0.886-0.979)) before pregnancy. CONCLUSION: Our data showed pregnancy outcomes in SLE patients can be improved in the HCQ treatment group with about 90% reduction of preeclampsia.
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Authors | M R Seo, J Chae, Y M Kim, H S Cha, S J Choi, S Oh, C-R Roh |
Journal | Lupus
(Lupus)
Vol. 28
Issue 6
Pg. 722-730
(May 2019)
ISSN: 1477-0962 [Electronic] England |
PMID | 30971164
(Publication Type: Journal Article)
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Chemical References |
- Antirheumatic Agents
- Uric Acid
- Hydroxychloroquine
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Topics |
- Adult
- Antirheumatic Agents
(therapeutic use)
- Female
- Gestational Age
- Humans
- Hydroxychloroquine
(therapeutic use)
- Infant, Newborn
- Logistic Models
- Lupus Erythematosus, Systemic
(complications, drug therapy, physiopathology)
- Lupus Nephritis
(epidemiology)
- Male
- Pre-Eclampsia
(epidemiology, prevention & control)
- Pregnancy
- Pregnancy Outcome
- Premature Birth
(epidemiology)
- Republic of Korea
- Retrospective Studies
- Uric Acid
(blood)
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