Abstract | BACKGROUND: Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected "pitted" erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. However, an increasing number of cases with positive direct antiglobulin test (DAT) haemolysis after AS have been reported. METHODS: All malaria cases seen at Hospital Clinic of Barcelona between 2015 and 2017 were retrospectively reviewed. Clinical, parasitological and laboratory data from patients treated with intravenous artesunate-specifically looking for delayed haemolysis and DAT-was collected. RESULTS: CONCLUSIONS:
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Authors | Daniel Camprubí, Arturo Pereira, Natalia Rodriguez-Valero, Alex Almuedo, Rosauro Varo, Climent Casals-Pascual, Quique Bassat, Denis Malvy, Jose Muñoz |
Journal | Malaria journal
(Malar J)
Vol. 18
Issue 1
Pg. 123
(Apr 08 2019)
ISSN: 1475-2875 [Electronic] England |
PMID | 30961636
(Publication Type: Case Reports, Letter)
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Chemical References |
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Topics |
- Administration, Intravenous
(adverse effects)
- Adolescent
- Adult
- Anemia, Hemolytic
(chemically induced, drug therapy)
- Antimalarials
(administration & dosage)
- Artesunate
(administration & dosage)
- Coombs Test
(statistics & numerical data)
- Female
- Hemolysis
(drug effects)
- Humans
- Malaria
(drug therapy)
- Male
- Middle Aged
- Retrospective Studies
- Spain
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