Comparison of the incidence of perioperative cardiovascular risk events among patients with and without a history of neoadjuvant chemotherapy.

Abstract

BACKGROUND:

Chemotherapy predisposes individuals to increased risk for future cardiac events.

METHODS:

In order to verify the hypothesis that neoadjuvant chemotherapy may be a risk factor for perioperative cardiovascular events, 122 patients who underwent radical mastectomy with general anesthesia were separated into two groups, the N group (neoadjuvant chemotherapy group) and the C group (control group), according to neoadjuvant chemotherapy history. Cardiovascular events were recorded in 24 hours after surgery.

RESULTS:

There were no differences in demographic characteristics such as age, body mass index and electrocardiogram between the two groups. The N group had higher atherosclerosis index, lower preoperative echocardiographic ejection fraction and hemoglobin values than the C group. The N group had significantly higher incidence of cardiovascular risk events (16.1%) than the C group (5%) (P<0.05). After binary logistic regression, neoadjuvant chemotherapy was identified as a risk factor of cardiovascular risk events.

CONCLUSIONS:

Patients who underwent neoadjuvant chemotherapy prior to radical mastectomy were more prone to cardiovascular risk events than those without chemotherapy history.

• Authors: Wen Zhang, Kangjie Xie, Shuang Fu, Huifang Jiang, Man Fang, Yanhong Lian, Wujun Geng, Jun Fang
• Journal: Minerva anestesiologica (Minerva Anestesiol) Vol. 85 Issue 8 Pg. 822-829 (Aug 2019) ISSN: 1827-1596 [Electronic] Italy
• PMID: 30938122 (Publication Type: Comparative Study, Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Anesthesia, General
• Atherosclerosis (complications, epidemiology)
• Breast Neoplasms (complications, drug therapy, surgery)
• Cardiovascular Diseases (epidemiology, etiology)
• Electrocardiography
• Female
• Humans
• Incidence
• Intraoperative Complications (epidemiology)
• Mastectomy
• Middle Aged
• Neoadjuvant Therapy (adverse effects)
• Perioperative Period
• Postoperative Complications (epidemiology)
• Retrospective Studies
• Stroke Volume
• Young Adult