Expression and clinical significance of FOS-like antigen 1 in gastric adenocarcinoma.

Abstract

BACKGROUND:

The overexpression of FOS-like antigen 1 (FOSL1) in several types of cancers was reported before. However, the expression and clinical significance of FOSL1 in gastric cancer (GC) have not been elucidated.

MATERIALS AND METHODS:

The expression of FOSL1 in 105 cases of GCs was detected with immunohistochemistry, and the mRNA of FOSL1 was investigated with quantitative real-time polymerase chain reaction(qRT-PCR) in 15 pairs of GCs and tumor adjacent tissues. With Chi-square test or Fisher test, we analyzed the correlation between FOSL1 expression and clinicopathological factors. With univariate analysis, we evaluated the correlations between clinicopathological factors including FOSL1 and overall survival (OS) rates. With multivariate analysis, we identified the independent prognostic risk factors of GC.

RESULTS:

The percentages of patients with low and high FOSL1 expression in our study accounted for 43.81% and 56.19%, respectively. The mRNA levels of FOSL1 in GCs were significantly higher than those in tumor adjacent tissues. FOSL1 expression was demonstrated to be significantly correlated with lymphatic invasion (P = 0.036) and TNM stage (P = 0.016). High expression of FOSL1 was significantly correlated with lower 5-year OS (P = 0.002), and FOSL1 expression was identified as an independent prognostic biomarker of GC (P = 0.001).

CONCLUSIONS:

FOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.

• Authors: Xiaoliang Zhu, Hui Liu, Zhenxing Xu, Yingchun Zhang
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 215 Issue 6 Pg. 152394 (Jun 2019) ISSN: 1618-0631 [Electronic] Germany
• PMID: 30935763 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Proto-Oncogene Proteins c-fos
• fos-related antigen 1

Topics

• Adenocarcinoma (metabolism, mortality, pathology)
• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Prognosis
• Proto-Oncogene Proteins c-fos (biosynthesis)
• Stomach Neoplasms (metabolism, mortality, pathology)