Abstract | BACKGROUND AND PURPOSE: METHODS: Fifty-six patients were randomized to treatment with 500 mg ter in die ALC, or placebo in this 28-week, double-blind, placebo-controlled trial. The primary outcome measure was the Korean version of Montreal Cognitive Assessment (MoCA-K). RESULTS: Following treatment with ALC, the cognitive function measured by the MoCA-K was significantly improved in the ALC-treated groups. However, other secondary outcomes were not statistically significant between ALC- and placebo-treated groups. In MoCA-K analysis, attention and language sub-items significantly favored the ALC-treated group. CONCLUSIONS: Compared with placebo, treatment with ALC 1,500 mg/day produced significant changes in MoCA-K in dementia patients with VCI. ALC was well tolerated in this population. Despite the study limitations, the findings suggested the potential benefits associated with the use of ALC in dementia patients with VCI.
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Authors | YoungSoon Yang, Hojin Choi, Chan-Nyoung Lee, Yong Bum Kim, Yong Tae Kwak |
Journal | Dementia and neurocognitive disorders
(Dement Neurocogn Disord)
Vol. 17
Issue 1
Pg. 1-10
(Mar 2018)
ISSN: 2384-0757 [Electronic] Korea (South) |
PMID | 30906386
(Publication Type: Journal Article)
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