Reactivation of Hepatitis B Virus Infection With Reverse Seroconversion Following Umbilical Cord Allogeneic Hematopoietic Cell Transplantation in a Hepatitis-B-Immune Patient: A Case Report.

Abstract

Hepatitis B virus (HBV) reactivation in patients with prior exposure to HBV and protective levels of hepatitis B surface antibody (HBsAb) is a rare phenomenon and is termed reverse seroconversion. We describe a case of reactivation of HBV infection following reverse seroconversion in a patient who underwent umbilical cord allogeneic hematopoietic cell transplantation (UHCT). The patient developed acute hepatitis with positive hepatitis B surface antigen (HBsAg) and HBV DNA in the context of prior strongly positive HBsAb. The patient was treated with oral tenofovir and liver function tests returned to normal 3 months later. Long-term monitoring for HBV reactivation should be considered in patients with prior exposure to HBV undergoing UHCT regardless of HBsAb status.

• Authors: D Singh, M Hassan, N Lim
• Journal: Transplantation proceedings (Transplant Proc) Vol. 51 Issue 2 Pg. 602-604 (Mar 2019) ISSN: 1873-2623 [Electronic] United States
• PMID: 30879599 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Antiviral Agents
• Hepatitis B Antibodies
• Tenofovir

Topics

• Aged
• Antiviral Agents (therapeutic use)
• Cord Blood Stem Cell Transplantation (adverse effects)
• Hepatitis B (drug therapy, etiology)
• Hepatitis B Antibodies (blood)
• Hepatitis B virus (physiology)
• Humans
• Male
• Seroconversion
• Tenofovir (therapeutic use)
• Virus Activation (physiology)