Abstract |
MUNIX method (Motor Unit Number Index) had been not used to assess number of motor neurons in post-polio syndrome in contrary to needle electromyography. OBJECTIVES: To confirm if MUNIX reflects motor unit loss and clinical stage and to assess difference in MUNIX and EMG results between muscles in different stage. METHODS: 132 Muscles (MUNIX) and 96 (EMG) in 12 patients were studied and divided into groups: with normal strength(N), stable weakness and atrophy(S), new weakness and atrophy(W). RESULTS: In PPS group MUNIX global was 561.36 ± 282.6 (right 6 muscles) and 561.27 ± 281.1 (left) significantly lower than in control group (six muscles 1139.6 ± 164.5) (p < 0.05). MUNIX global correlated with MRC global. MUNIX was greater in muscles with normal strength (95-100% of normal values) than in those with stable weakness (48%-0% of normal values) and new weakness (65%-0% of normal values). Respectively to clinical stage of muscle MUP (motor unit potential) amplitude increased to 350% of normal value, from 250% to 110%, and from 300% to 700%. No correlation was found between MUP parameters and MRC values. CONCLUSIONS: MUNIX reflects motor dysfunction and could be a good biomarker for loss of motor neurons in PPS.
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Authors | Malgorzata Gawel, Ewa Zalewska, Elżbieta Szmidt-Salkowska, Marta Lipowska, Anna Lusakowska, Anna M Kaminska, Anna Kostera-Pruszczyk |
Journal | Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
(J Electromyogr Kinesiol)
Vol. 46
Pg. 35-40
(Jun 2019)
ISSN: 1873-5711 [Electronic] England |
PMID | 30878651
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Biomarkers
- Electromyography
- Female
- Humans
- Male
- Middle Aged
- Motor Neurons
(physiology)
- Muscle, Skeletal
(physiology)
- Needles
- Postpoliomyelitis Syndrome
(physiopathology)
- Severity of Illness Index
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