Abstract | OBJECTIVES: DESIGN: Pre-post study. SETTING: Large academic medical center in the United States. PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Hospital and ICU length of stay were reduced by 23.6% and 38%, respectively. The relative risk of remaining in the hospital at day 7 (0.51; p = 0.022) and day 14 (0.28; p = 0.044) were significantly reduced by the moderate-intensity insulin therapy strategy. The relative risk of remaining in the ICU at 48 hours was significantly lower in the moderate-intensity insulin therapy cohort (0.34; p = 0.0048). The prevalence (35% vs 1%; p = 0.0003) and relative risk (0.028; p = 0.0004) of hypoglycemia were significantly lower in the moderate-intensity insulin therapy cohort. Glycemic variability decreased by 28.6% (p < 0.0001). There was no difference in the time to anion gap closure (p = 0.123). CONCLUSIONS:
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Authors | Rachelle L Firestone, Patricia L Parker, Komal A Pandya, Machelle D Wilson, Jeremiah J Duby |
Journal | Critical care medicine
(Crit Care Med)
Vol. 47
Issue 5
Pg. 700-705
(05 2019)
ISSN: 1530-0293 [Electronic] United States |
PMID | 30855284
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Hypoglycemic Agents
- Insulin
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Topics |
- Adult
- Cohort Studies
- Critical Illness
(therapy)
- Diabetic Ketoacidosis
(drug therapy)
- Female
- Humans
- Hyperglycemia
(drug therapy)
- Hyperglycemic Hyperosmolar Nonketotic Coma
(drug therapy)
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(therapeutic use)
- Insulin Resistance
- Length of Stay
(statistics & numerical data)
- Male
- Middle Aged
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