The antitumor effect of resveratrol on nasopharyngeal carcinoma cells.

Abstract

The anti-tumor effect of resveratrol has been observed in many cancers. Here, we examined the anti-tumor activity of resveratrol in human nasopharyngeal carcinoma (NPC) cells. Resveratrol, in a dose-dependent manner, inhibited proliferation related proteins (Ki67, PCNA), and cell proliferation, and reduced apoptosis related proteins (cleaved caspase-3, cleaved caspase-9) and apoptosis in nasopharyngeal carcinoma cells. Resveratrol treatment inhibited the increased-expression of Survivin in NPC cells, while the overexpressed Survivin counteracted the effect of resveratrol on cell proliferation and apoptosis in NPC cells, thus establishing Resveratrol-induced reduction in increased-survivin in NPC cells as the underlying mechanism. These findings show that resveratrol can be used to modify the cell growth and death in NPC cells.

• Authors: Huisheng Xiong, Jun Cheng, Shen Jiang, Jun Wen, Yang Jian, Lu Wei, Zhang Zhe, Jiang Fu-Qiang, Xie Peng
• Journal: Frontiers in bioscience (Landmark edition) (Front Biosci (Landmark Ed)) Vol. 24 Issue 5 Pg. 961-970 (03 01 2019) ISSN: 2768-6698 [Electronic] Singapore
• PMID: 30844723 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• BIRC5 protein, human
• Survivin
• Resveratrol

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis
• Cell Cycle
• Cell Line, Tumor
• Cell Proliferation
• Cell Survival (drug effects)
• Gene Expression Regulation, Neoplastic
• Humans
• Nasopharyngeal Carcinoma (drug therapy, pathology)
• Resveratrol (pharmacology)
• Signal Transduction (drug effects)
• Survivin (metabolism)