Intratumoral Injection of Hypertonic Glucose in Treating Refractory Pneumothorax Caused by Microwave Ablation: a Preliminary Study.

Abstract

PURPOSE:

The purpose of this technical report is to describe the technique of intratumoral injection of hypertonic glucose combined with low-negative pressure drainage to treat refractory pneumothorax (RP) after microwave ablation (MWA) of lung tumors.

MATERIALS AND METHODS:

Between September 2016 and May 2018, four patients who developed RP after MWA of peripheral lung cancer were managed by a combined method, including intratumoral injection of hypertonic glucose and catheter drainage under low-negative pressure. Blood gas values were recorded and compared before the treatment and one-week posttreatment. All patients were followed up for at least one month to monitor the possible recurrence of pneumothorax by chest CT.

RESULTS:

All patients were successfully treated. One patient received the intratumoral injection of hypertonic glucose twice, while the remaining three patients received a single injection. The technical success rate was 100%. Dyspnea related to RP was significantly relieved in all patients, and PaO2 and SaO2 values were higher than those measured before treatment. No patient suffered a recurrence of pneumothorax during the follow-up.

CONCLUSION:

The combined method of intratumoral injection of hypertonic glucose and continuous catheter drainage under low-negative pressure might be an effective method to manage RP caused by MWA.

• Authors: Dongdong Wang, Xiaoguang Li, Wanjiang Yu
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 42 Issue 6 Pg. 915-919 (Jun 2019) ISSN: 1432-086X [Electronic] United States
• PMID: 30843091 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucose

Topics

• Ablation Techniques (adverse effects)
• Aged
• Aged, 80 and over
• Female
• Follow-Up Studies
• Glucose (administration & dosage, therapeutic use)
• Humans
• Injections, Intralesional
• Lung (diagnostic imaging)
• Lung Neoplasms (surgery)
• Male
• Microwaves
• Pneumothorax (diagnostic imaging, drug therapy, etiology)
• Tomography, X-Ray Computed
• Treatment Outcome