Pneumothorax

An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.

Also Known As:

Pneumothorax, Primary Spontaneous; Pressure Pneumothorax; Primary Spontaneous Pneumothorax; Spontaneous Pneumothorax; Tension Pneumothorax; Pneumothorax, Pressure; Pneumothorax, Spontaneous; Pneumothorax, Tension; Spontaneous Pneumothorax, Primary

Networked: 7800 relevant articles (337 outcomes, 464 trials/studies)

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 6273
- Pleural Diseases: 455
  - Pneumothorax: 7800
    - Catamenial pneumothorax: 63
    - Pulmonary Bullae Causing Pneumothorax

Related Diseases

1.	Pleural Effusion (Pleural Effusions)
2.	Blister (Bulla)
3.	Wounds and Injuries (Trauma)
4.	Pneumothorax
5.	Hemorrhage

Experts

1.	Chen, Jin-Shing: 24 articles (01/2024 - 01/2004)
2.	Hiraki, Takao: 17 articles (06/2022 - 10/2006)
3.	Kanazawa, Susumu: 17 articles (09/2021 - 10/2006)
4.	Kurihara, Masatoshi: 16 articles (10/2023 - 07/2006)
5.	Hsu, Hsao-Hsun: 15 articles (11/2021 - 01/2004)
6.	Davis, Peter G: 14 articles (01/2023 - 02/2008)
7.	Gobara, Hideo: 14 articles (09/2021 - 10/2006)
8.	Soll, R F: 14 articles (10/2007 - 01/2000)
9.	Seyama, Kuniaki: 13 articles (10/2023 - 12/2005)
10.	Iguchi, Toshihiro: 13 articles (06/2022 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumothorax:

1.	Talc FDA Link 10/01/1994 - "We conclude from these observations that the insufflation of 2 g of talc into the pleural space is a safe effective treatment for control of recurrent spontaneous pneumothorax." 11/01/2004 - "Feasibility, safety and efficacy of VATS for management of recurrent primary spontaneous pneumothorax following thoracoscopic talc poudrage are strongly suggested." 07/01/2012 - "The aim of this study was to compare talc poudrage and pleural abrasion in the treatment of spontaneous pneumothorax. " 10/01/2023 - "There was one case of recurrent ipsilateral pneumothorax in a patient who had no inflammatory response to talc insufflation. " 01/01/2020 - "During a median follow-up period of 70.0 months (95% confidence interval 66.6-73.4), pneumothorax recurred in 79 patients (9.4%); among these, 29 underwent redo surgery; 34, chest drain/talc slurry; and 16, clinicoradiological observation. "
2.	Surface-Active Agents (Surfactants)IBA 01/01/2001 - "The meta-analysis shows that the use of natural surfactant rather than synthetic surfactant results in a significant reduction in the risk of pneumothorax (typical relative risk 0.63, 95% CI 0.53, 0.75; typical risk difference -0.04, 95% CI -0.06, -0.03) and the risk of mortality (typical relative risk 0.87, 95% CI 0.76, 0.98; typical risk difference -0.02, 95% CI -0.05, 0.00). " 07/01/1998 - "Modified natural surfactant is more effective in reducing the risk of pneumothorax and increasing the chance for survival without BPD than is synthetic surfactant. " 01/21/2009 - "In infants with established respiratory distress, a policy of multiple doses of animal derived surfactant extract resulted in greater improvements regarding oxygenation and ventilatory requirements, a decreased risk of pneumothorax and a trend toward improved survival.In" 01/01/2000 - "In infants with established respiratory distress, a policy of multiple doses of natural surfactant extract results in greater improvements regarding oxygenation and ventilatory requirements, a decreased risk of pneumothorax and a trend toward improved survival. " 01/01/2020 - "Intervention group infants also showed lower oxygenation requirements during the first 72 h post surfactant administration and a reduced incidence of pneumothorax. "
3.	Oxygen (Dioxygen)IBA 01/01/1993 - "Patients with severe airspace enlargement (2.6-40 mm internal diameter) had a significantly greater incidence of pneumothorax (8 versus 2, p < 0.05), were ventilated using higher peak airway pressures (56 +/- 18 cmH2O versus 44 +/- 10 cmH2O, p < 0.05) and tidal volumes (12 +/- 3 ml/kg versus 9 +/- 2 ml/kg, p < 0.05), were exposed significantly longer to toxic levels of oxygen (8.6 +/- 9.4 days versus 1.9 +/- 2 days at FIO2 > 0.6, p < 0.05) and lost more weight (6.3 +/- 9.2 kg versus 0.75 +/- 5.8 kg, p < 0.05) than patients with mild airspace enlargement (1-2.5 mm internal diameter). " 10/15/2013 - "Among 73 cases of pneumothorax (n = 73, 11.7%), 65 cases (n = 65, 10.4%) of mild pneumothorax (lung compression < 20%) were cured by sufficient oxygen inhalation and repose while 8 cases (1.3%) suffered lung compression ≥ 75% recovered via closed thoracic drainage. " 06/01/2000 - "Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. " 01/01/2023 - "Recent studies on the treatment of a small, closed pneumothorax involve conservative care, which includes close observation of the patient and monitoring supplemental oxygen. " 06/30/2012 - ""We undertook this study to investigate the adequate oxygen concentration that can be applied safely to the treatment of pneumothorax. "
4.	Polyglycolic Acid (Polyglycolide)IBA 10/01/2021 - "Pleural coverage with a polyglycolic acid sheet is suggested to be effective in preventing postoperative recurrence of pneumothorax compared with non-coverage in relatively young patients." 01/18/2022 - "The purpose of this study was to clarify the efficacy of the combination of low-voltage coagulation plus staple line coverage with a polyglycolic acid sheet after bullectomy for primary spontaneous pneumothorax to prevent a postoperative recurrence. " 10/01/2021 - "Efficacy of pleural coverage with polyglycolic acid sheet after bullectomy for postoperative recurrence of spontaneous pneumothorax in young patients: a multi-institutional cohort study." 05/27/2020 - "A clinical study of efficacy of polyglycolic acid patch in surgery for pneumothorax:a systematic review and meta-analysis." 04/01/2017 - "A clinical study of efficacy of polyglycolic acid sleeve after video-assisted thoracoscopic bullectomy for primary spontaneous pneumothorax."
5.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 04/01/2024 - "This study presents a new minimally invasive method for treating persistent pneumothorax using platelet-rich plasma-fibrin glue (PRP-FG). " 04/01/2024 - "Persistent pneumothorax treatment following congenital cardiac surgery by platelet-fibrin glue." 06/01/2023 - "Use of Fibrin Glue in the Treatment of Persistent Pneumothorax in Premature Infants at the Limit of Viability: Ethical Issues and Two and A Half Years Follow-Up." 08/01/2021 - "Applying Fibrin Glue under Pleurography for Intractable Secondary Spontaneous Pneumothorax." 07/01/2015 - "Pneumothorax with intractable air leakage often needs interventional treatments like endobroncheal occlusion (EBO) or thoracographic fibrin glue sealing method (TGF) as well as urgent thoracoscopic surgery. "
6.	lipoarabinomannan (LAM)IBA 01/01/2017 - "In our base case analysis, screening for the presence of BHD, LAM, or PLCH in patients presenting with a spontaneous pneumothorax was cost effective, with a marginal cost-effectiveness ratio of $1,427 per quality-adjusted life-year gained. " 01/01/2022 - "In our study, multivariate logistic regression was applied to a cross-sectional cohort to investigate factors associated with pneumothorax in LAM patients. " 03/26/2024 - "Complications including pneumothorax and loss of lung function are significant and similar to sporadic LAM. " 11/01/2023 - "The authors report a case of LAM presenting with a pneumothorax, which due to its atypical imaging characteristics, mimicked another uncommon cystic disease. " 05/01/2023 - "This case highlights the benefit of IPC with an ambulatory pneumothorax device in a patient with LAM with PAL."
7.	Minocycline (Cyclops)FDA LinkGeneric 11/01/2011 - "The current study is designed to compare the effectiveness of brushing the pleura vs. instillation of minocycline for the management of primary spontaneous pneumothorax, and to assess the sensitivity of echography in defining areas of defects. " 03/01/2012 - "After a mean follow-up of 26.1 months, recurrent ipsilateral pneumothorax occurred in 3 patients (3.8%) in the pleurectomy group and 3 patients (3.8%) in the abrasion/minocycline group. " 03/01/2012 - "To compare the efficacy and safety between apical pleurectomy and pleural abrasion with minocycline in primary spontaneous pneumothorax (PSP) with high recurrence risk. " 07/01/2008 - "Intrapleural minocycline following simple aspiration for initial treatment of primary spontaneous pneumothorax." 03/01/2006 - "After a mean follow-up of 29 mo (12-47 mo), recurrent ipsilateral pneumothorax was noted in two patients in the minocycline group and eight patients in the observation group (p = 0.044 by the Kaplan-Meier method and log-rank test). "
8.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2013 - "Despite treatment with a combination of antibiotics showing in vitro susceptibility, the pathogen persisted in the respiratory secretions for longer than 6 months and the patient suffered a spontaneous pneumothorax 14 months into treatment. " 04/01/2010 - "Because of the increasing respiratory distress an intercostal drain was placed in the left pneumothorax and broad-spectrum antibiotics were administered. " 04/01/2000 - "Therapeutic pneumothorax (TP) proved its efficacy in pre-antibiotic era, so one can assume that it can be applied with the same success in multidrug resistant TB. " 11/11/1978 - "Patients suffering from uncomplicated pneumothorax, haemothorax or haemopneumothorax of clinical significance are treated with fluid replacement, intercostal under-water drainage, antibiotics and routine physiotherapy. " 03/01/1964 - "[ON THE REGRESSION OF TUBERCULAR CAVERN AFTER CHEMO-ANTIBIOTIC TREATMENT ALONE OR WITH INTRAPLEURAL PNEUMOTHORAX. "
9.	SolutionsIBA 07/29/2022 - "Artificial intelligence (AI) techniques can be a solution for delayed or misdiagnosed pneumothorax. " 05/01/2022 - "We evaluated a commercially available AI solution intended to facilitate the detection of three chest abnormalities (nodule/masses, consolidation, and pneumothorax) against a reference standard to measure its diagnostic performance. " 01/01/2021 - "Ambulatory management of secondary spontaneous pneumothorax: a mirage, or a solution on the horizon?" 11/01/2018 - "These models may provide a high specificity screening solution to detect moderate or large pneumothorax on images collected when human review might be delayed, such as overnight. " 09/01/2013 - "Our proposed new method of ipsilateral opposite-side aspiration offers a solution for patients who remain with resistant pneumothorax after simple aspiration."
10.	Penicillins (Penicillin)FDA Link 11/01/1947 - "The adjuvant role of penicillin in the prophylaxis and treatment of fluid complications from extra-pleural pneumothorax." 02/01/1947 - "Penicillin and fistulization of the pouch of extra-pleural pneumothorax." 01/01/1945 - "Treatment of two complications of extra-pleural pneumothorax, and their rescue with penicillin." 08/02/1954 - "[Penicillin in thoracoplasty and extrapleural pneumothorax]." 07/01/1949 - "A case of pyo-pneumothorax cured by medical treatment; vacuum punctures and intr-pleural injections of penicillin."

Therapies and Procedures

1.	Pleurodesis 01/01/2000 - "VATS combined with mechanical brush pleurodesis using the electrical brush system is a highly effective and safe treatment for patients with recurrent primary spontaneous pneumothorax." 09/01/2007 - "Spontaneous pneumothorax is a common problem and in patients at risk of recurrence, excision of the source of the air leak and pleurodesis is very effective in reducing further episodes. " 01/01/1988 - "We conclude that thoracoscopy enables accurate assessment of the type of pneumothorax, and can play an important role in the management of SP. Chemical pleurodesis causes a significant reduction of the recurrence rate in the treatment of idiopathic SP." 02/01/2004 - "We describe an 8-year-old boy with acute lymphoblastic leukaemia complicated by chronic GVHD-related BO, and subsequent pneumothorax with persistent air leak, who was treated successfully with autologous blood pleurodesis." 10/01/2020 - "This meta-analysis demonstrated that combined intervention with mechanical and chemical pleurodesis for spontaneous pneumothorax may be more effective in preventing recurrence than mechanical pleurodesis alone. "
2.	Chest Tubes (Chest Tube) 02/09/2024 - "Utilizing autologous blood patch intraparenchymal injection during the coaxial needle retraction process post-lung biopsy is highly effective in diminishing both the incidence of pneumothorax and consequent chest tube placement requirement." 01/01/2023 - "Adults aged 18-50 years with complete primary spontaneous pneumothorax (total separation of the lung from the chest wall), recruited at 31 French hospitals from 2009 to 2015, received simple aspiration (n = 200) or chest tube drainage (n = 202) as first-line treatment. " 12/01/2009 - "In 210 (86.4%), the pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement. " 11/01/2006 - "In 87 of the 102 patients (85.3%), the pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement, but chest tube placement was required in 15 patients. " 10/01/2006 - "The pneumothorax had resolved completely on follow-up chest radiographs without chest tube placement in 121 of the 133 pneumothoraces (91.0%). "
3.	Thoracostomy 12/16/2022 - "Tube thoracostomy is the most effective treatment for pneumothorax, and on the battlefield, is lifesaving. " 01/01/2020 - "To compare the effectiveness and safety between needle aspiration (NA) and closed thoracostomy (CT) method in adult spontaneous pneumothorax (SP) patients and to explore the most effective and safe protocol by using meta-analysis method. " 08/01/1994 - "Most cases of spontaneous pneumothorax can be handled either expectantly or by tube thoracostomy with good results. " 12/01/2020 - "Reactor™ thoracostomy was effective, expedient, and may provide a useful and technically simpler first-line treatment for tension pneumothorax or tension-induced pulseless electrical activity." 06/01/2017 - "A short cut review was carried out to see if 'finger' thoracostomy is a safe and effective method of treating a tension pneumothorax in a pre-hospital setting. "
4.	Therapeutics 06/01/2012 - "Cats who present with spontaneous pneumothorax may be treated successfully with non-surgical therapies and appear to have a better prognosis than previously extrapolated from canine studies." 04/01/2024 - "We searched PubMed and Google Scholar from inception until June 24, 2020, for randomized controlled trials (RCTs) comparing observational therapy with conventional therapy for the treatment of adult pneumothorax. " 01/01/2023 - "Study of the Relative Frequency of Spontaneous Pneumothorax Recurrence with Two Policy Therapies: A Clinical Trial." 07/20/2022 - "The aim of this study was to investigate the incidence, clinical characteristics, risk factors, therapy and perinatal outcome in neonates with pneumothorax in a tertiary care center. " 10/01/2018 - "In this meta-analysis of randomized controlled trials comparing SC vs. DC ICD device or programming, there was no significant difference in inappropriate therapies, mortality, pneumothorax, or lead dislodgement. "
5.	Catheters 01/01/2022 - "Pleural catheter placement following post-lung biopsy pneumothorax was the most common non-complex bundled case with a significant reduction in TRoom when performed via Angio-CT compared to control (99 vs. 163 min, p < 0.0001). " 01/01/2020 - "No significant differences in mortality between the two groups were found (28.0% pigtail group versus 26.3% straight drain group; p > 0.05).Conclusion: Pigtail catheters are a safe and effective alternative to traditional chest drains for infants with pneumothorax. " 03/01/2013 - "Small-bore pigtail catheters have been found to be effective in the treatment of primary spontaneous pneumothorax (PSP) in adults. " 10/01/2012 - "Our findings suggest that drainage via a catheter or via a CT is similarly effective in the management of pneumothorax. " 12/01/1990 - "To assess the efficacy of simple aspiration as a treatment for pneumothorax, 40 consecutive pneumothoraces (28 spontaneous, 12 iatrogenic, all estimated at greater than or equal to 20% collapse on visual inspection of the chest X-ray) in 38 symptomatic patients were treated initially by small-lumen catheter (SLC) aspiration. "