Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.

Abstract

OBJECTIVE:

To investigate the association between single nucleotide polymorphisms (SNPs) in six candidate genes (enamelin [ ENAM]; tuftelin 1 [ TUFT1]; matrix metallopeptidase 13 [ MMP13]; interleukin 1 beta [ IL1B]; interleukin 10 [ IL10]; interleukin 1 receptor antagonist [ IL1RN]) and dental caries in children from northwest China.

METHODS:

This case-control study enrolled children (12-15 years) who underwent routine dental examinations. The children were divided into two groups based on the presence of dental caries. A saliva sample was collected and seven SNPs (rs3806804A/G in ENAM, rs3811411T/G in TUFT1, rs2252070A/G and rs597315A/T in MMP13, rs1143627C/T in IL1B, rs1800872A/C in IL10 and rs956730G/A in IL1RN) were genotyped.

RESULTS:

A total of 357 children were enrolled in the study: 161 with dental caries and 196 without dental caries. No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries. A significant relationship was found between the IL1B rs1143627C/T polymorphism and dental caries susceptibility with those carrying the rs1143627CT genotype having a lower risk of dental caries compared with those carrying the CC genotype (odds ratio 0.557; 95% confidence interval 0.326, 0.952).

CONCLUSION:

The IL1B rs1143627C/T polymorphism may be associated with dental caries susceptibility in children from northwest China.

• Authors: Xiao-Pan Hu, Tian-Zhu Song, Yan-Yan Zhu, Ling-Li Wu, Xuan Zhang, Jian-Ye Zhou, Zhi-Qiang Li
• Journal: The Journal of international medical research (J Int Med Res) Vol. 47 Issue 4 Pg. 1696-1704 (Apr 2019) ISSN: 1473-2300 [Electronic] England
• PMID: 30803280 (Publication Type: Journal Article)

Chemical References

• Dental Enamel Proteins
• ENAM protein, human
• Extracellular Matrix Proteins
• IL10 protein, human
• IL1B protein, human
• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1beta
• tuftelin
• Interleukin-10
• MMP13 protein, human
• Matrix Metalloproteinase 13

Topics

• Adolescent
• Asian People (genetics)
• Case-Control Studies
• Child
• Dental Caries (genetics, pathology)
• Dental Enamel Proteins (genetics)
• Extracellular Matrix Proteins (genetics)
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin 1 Receptor Antagonist Protein (genetics)
• Interleukin-10 (genetics)
• Interleukin-1beta (genetics)
• Male
• Matrix Metalloproteinase 13 (genetics)
• Polymorphism, Single Nucleotide
• Prognosis