Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women.

Abstract

BACKGROUND:

Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women.

SETTING:

In a case-control study nested within the Women's Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by the presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques.

METHODS:

Conditional logistic regression estimated the association of MP-TF activity with the presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (high-sensitivity C-reactive protein, IL-6, sCD14, sCD163, Gal-3, and Gal-3BP).

RESULTS:

Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% confidence interval: 1.06 to 14.07, P = 0.04). The association was attenuated after further adjustment for IL-6 but was unaffected by adjustment for other biomarkers including those denoting monocyte activation.

CONCLUSIONS:

Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.

• Authors: Juan Lin, Xiaonan Xue, Kathryn Anastos, Mardge H Cohen, Stephen J Gange, Jason M Lazar, Chenglong Liu, Wendy J Mack, Phyllis C Tien, Cathy Tilley, Howard N Hodis, Alan L Landay, Russell P Tracy, Robert C Kaplan, David B Hanna
• Journal: Journal of acquired immune deficiency syndromes (1999) (J Acquir Immune Defic Syndr) Vol. 81 Issue 1 Pg. 36-43 (05 01 2019) ISSN: 1944-7884 [Electronic] United States
• PMID: 30789451 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Thromboplastin

Topics

• Adult
• Carotid Stenosis (blood, diagnostic imaging, etiology)
• Case-Control Studies
• Female
• HIV Infections (blood, complications)
• Humans
• Middle Aged
• Thromboplastin (analysis)
• Ultrasonography