Microvascular density, macrophages, and mast cells in human clear cell renal carcinoma with and without bevacizumab treatment.

Abstract

BACKGROUND:

Clear cell renal cell carcinoma (ccRCC) represents a highly vascularized aggressive kidney cancer. Due to ccRCC chemotherapy resistance, antiangiogenesis is one of the most innovative targeted therapies for this tumor. The tumor microenvironment exerts important roles in tumor growth, angiogenesis, and metastatic escape.

MATERIALS AND METHODS:

In this study, we investigated the composition of tumor cell microenvironment including mast cells, macrophages, and microvascular density in ccRCC tumor tissues collected from patients who underwent nephrectomy treated or not with bevacizumab as neoadjuvant therapy before surgery.

RESULTS:

The results of this study indicate that bevacizumab-treated ccRCC samples present reduced microvascular density as well as a lower number of CD68-positive macrophages and tryptase-positive mast cells in comparison with the untreated patients.

CONCLUSIONS:

It follows that the antiangiogenic activity of bevacizumab may be due to a direct effect on angiogenic cytokines released by tumor cells and an indirect effect on the release of pro-angiogenic factors by inflammatory stromal cells.

• Authors: Roberto Tamma, Monica Rutigliano, Giuseppe Lucarelli, Tiziana Annese, Simona Ruggieri, Eliano Cascardi, Anna Napoli, Michele Battaglia, Domenico Ribatti
• Journal: Urologic oncology (Urol Oncol) Vol. 37 Issue 6 Pg. 355.e11-355.e19 (06 2019) ISSN: 1873-2496 [Electronic] United States
• PMID: 30738745 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Angiogenesis Inhibitors
• Bevacizumab

Topics

• Adult
• Aged
• Aged, 80 and over
• Angiogenesis Inhibitors (therapeutic use)
• Bevacizumab (therapeutic use)
• Carcinoma, Renal Cell (blood supply, drug therapy, pathology)
• Female
• Humans
• Kidney Neoplasms (blood supply, drug therapy, pathology)
• Macrophages
• Male
• Mast Cells
• Microvessels
• Middle Aged
• Tumor Microenvironment