Differences in Human Leukocyte Antigen Expression Between Breast Implant-Associated Anaplastic Large Cell Lymphoma Patients and the General Population.

Abstract

BACKGROUND:

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell lymphoma associated with textured-surface breast implants. Human leukocyte antigen (HLA) polymorphisms have been described with other forms of lymphoma, but have not been described for BIA-ALCL.

OBJECTIVES:

The aim of this study was to evaluate HLA polymorphisms in BIA-ALCL patients.

METHODS:

We prospectively evaluated HLA alleles in patients with BIA-ALCL. HLA was analyzed by probe-based sequence-specific testing and sequence-based typing. The frequencies of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles were evaluated. Allele frequencies in the Caucasian European general population were obtained from the National Marrow Donor Program to serve as normative controls. We estimated the relative risk of BIA-ALCL with 95% confidence intervals from a t test.

RESULTS:

Thirteen patients who had undergone BIA-ALCL and HLA testing were identified from 2017 to 2018. Patients carried 10, 11, and 9 HLA-A, HLA-B, and HLA-C alleles, respectively. There were 8 DRB1 alleles and 5 DQB1 alleles in the BIA-ALCL patients. The A*26 allele occurred significantly more frequently in the general population compared with BIA-ALCL patients (0.2992 vs 0.07692, P < 0.001).

CONCLUSIONS:

Our results identify a difference between HLA A*26 in patients who develop BIA-ALCL and the general population, and may signify genetic susceptibility factors responsible for germline genetic variation in HLA in patients with BIA-ALCL. Further work is needed to elucidate if these alleles are predictive for BIA-ALCL in women with textured-surface breast implants.Level of Evidence: 4.

• Authors: Sarah E Tevis, Kelly K Hunt, Roberto N Miranda, Caitlin Lange, Charles E Butler, Mark W Clemens
• Journal: Aesthetic surgery journal (Aesthet Surg J) Vol. 39 Issue 10 Pg. 1065-1070 (09 13 2019) ISSN: 1527-330X [Electronic] England
• PMID: 30715139 (Publication Type: Journal Article)
• Copyright: © 2019 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: [email protected].

Chemical References

• HLA Antigens

Topics

• Adult
• Aged
• Alleles
• Bone Marrow (pathology)
• Breast (pathology, surgery)
• Breast Implantation (adverse effects, instrumentation)
• Breast Implants (adverse effects)
• Breast Neoplasms (surgery)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotyping Techniques
• HLA Antigens (genetics)
• Humans
• Lymphoma, Large-Cell, Anaplastic (diagnosis, etiology, genetics, pathology)
• Mastectomy (adverse effects)
• Middle Aged
• Prospective Studies
• Surface Properties