Abstract | BACKGROUND: Approximately 10% to 30% of Alzheimer disease (AD) patients progress rapidly in severity and become more dependent on caregivers. Although several studies have investigated whether imaging biomarkers such as medial temporal atrophy ( MTA) and posterior atrophy (PA) are useful for predicting the rapid progression of AD, their results have been inconsistent. OBJECTIVE: The study aims to investigate the association of visually rated MTA and PA with rapid disease progression in AD. METHODS: This was a retrospective cohort study of 159 AD patients who were initially diagnosed with mild AD and were followed for 1 year to determine whether they progressed rapidly (a decrease of three points or more on the Mini-Mental State Examination over 1 year). We used 5-point and 4-point visual rating scales to assess MTA and PA, respectively. MTA and PA scores for each patient were dichotomized as normal (without atrophy) or abnormal ( atrophy). We performed a logistic regression analysis to determine the odds ratios ( ORs) of MTA and PA for rapid disease progression with adjustment for covariates. RESULTS: Within the study population, 47 (29.6%) patients progressed rapidly. Visual assessment of the magnetic resonance imaging (MRI) scans revealed that 112 patients (70.4%) showed MTA, whereas 80 patients (50.3%) showed PA. The ORs with 95% confidence intervals for MTA and PA were 1.825 (0.819-4.070) and 2.844 (1.378-5.835), respectively. The association of visually assessed PA, but not MTA, with rapid progression was significant after adjustment for covariates. CONCLUSION: In patients with mild AD, visual assessment of PA exhibits independent predictive value for rapid disease progression.
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Authors | Jeewon Suh, Young Ho Park, Hang-Rai Kim, Jae-Won Jang, Min Ju Kang, Jimin Yang, Min Jae Baek, SangYun Kim |
Journal | International journal of geriatric psychiatry
(Int J Geriatr Psychiatry)
Vol. 34
Issue 4
Pg. 625-632
(04 2019)
ISSN: 1099-1166 [Electronic] England |
PMID | 30714196
(Publication Type: Journal Article)
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Copyright | © 2019 John Wiley & Sons, Ltd. |
Topics |
- Aged
- Alzheimer Disease
(diagnosis)
- Atrophy
- Cognitive Dysfunction
(diagnosis)
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Retrospective Studies
- Temporal Lobe
(diagnostic imaging)
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