Abstract | OBJECTIVES: BACKGROUND: NSVT has been shown to be independently associated with sudden cardiac death (SCD) in HCM. Previous studies have found LGE on cardiac magnetic resonance (CMR) to be independently associated with NSVT. METHODS: Seventy-three patients who had 14-day Holter monitoring for either risk stratification for SCD (n = 62) or evaluation of atrial fibrillation (n = 11) on a CMR study were included. Areas of LGE in left ventricle (LV) were visually identified and analyzed quantitatively for both high (≥6 SD above the mean signal intensity of normal myocardium) and intermediate (≥4 but <6 SD) LGE signal intensity. RESULTS: Patients with more extensive LGE had longer (P = 0.0028) and more frequent (P = 0.02) episodes of NSVT. In univariate analyses, frequency of NSVT was associated with LGE extent (rs = 0.43, P = 0.001), LV ejection fraction (rs = -0.38, P < 0.001), LV mass (rs = 0.32, P = 0.005), LV maximal wall thickness (rs = 0.28, P = 0.016), and left atrium diameter (rs = 0.29, P = 0.001); maximal length of NSVT was associated with LGE extent (rs = 0.52, P < 0.001), LV ejection fraction (rs = -0.44, P < 0.001), LV mass (rs = 0.37, P = 0.001), and left atrium diameter (rs = 0.3, P < 0.001). In multivariable analyses, LGE extent remained the sole variable independently associated with frequency (P = 0.001) and maximal length of episodes of NSVT (P = 0.001). No significant association was found between the rate of NSVT and LGE extent. CONCLUSIONS: LGE extent is independently associated with a greater burden and longer episodes of NSVT in HCM. These findings support the association between myocardial fibrosis as represented by LGE and ventricular tachyarrhythmias in HCM.
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Authors | Adaya Weissler-Snir, Waseem Hindieh, Danna A Spears, Arnon Adler, Harry Rakowski, Raymond H Chan |
Journal | Journal of cardiovascular electrophysiology
(J Cardiovasc Electrophysiol)
Vol. 30
Issue 5
Pg. 651-657
(05 2019)
ISSN: 1540-8167 [Electronic] United States |
PMID | 30680853
(Publication Type: Journal Article)
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Copyright | © 2019 Wiley Periodicals, Inc. |
Chemical References |
- Contrast Media
- Gadolinium DTPA
|
Topics |
- Adult
- Aged
- Atrial Function, Left
- Atrial Remodeling
- Cardiomyopathy, Hypertrophic
(complications, diagnostic imaging, physiopathology)
- Contrast Media
(administration & dosage)
- Electrocardiography, Ambulatory
- Female
- Fibrosis
- Gadolinium DTPA
(administration & dosage)
- Heart Rate
- Humans
- Magnetic Resonance Imaging, Cine
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Risk Factors
- Tachycardia, Ventricular
(diagnosis, etiology, physiopathology)
- Time Factors
- Ventricular Function, Left
- Ventricular Remodeling
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