Abstract | BACKGROUND: METHODS: Male Sprague-Dawley rats weighing 100-120 g received L5,6 spinal nerve ligation to induce neuropathic pain. Rats showing allodynia were implanted with intrathecal (i.t.) catheter to administer the experimental drugs into the subarachnoid space. To induce olerance to morphine, 15 microgram of morphine was injected via i.t. catheter twice a day for 7 days, and the effect of i.t. gabapentin on the paw withdrawal threshold was examined using the von Frey test before and after the development of morphine tolerance. RESULTS:
Ligation of spinal nerves decreased the paw withdrawal threshold. Intrathecal morphine initially increased the paw withdrawal threshold, but this effect decreased gradually over time. However, morphine tolerance did not influence the effect of gabapentin on withdrawal threshold. CONCLUSIONS:
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Authors | Jin Hua Cui, Hyung Gon Lee, Woong Mo Kim, Hong Beom Bae, Myung Ha Yoon, Jeong Il Choi |
Journal | Korean journal of anesthesiology
(Korean J Anesthesiol)
Vol. 56
Issue 1
Pg. 74-78
(Jan 2009)
ISSN: 2005-7563 [Electronic] Korea (South) |
PMID | 30625698
(Publication Type: Journal Article)
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