Clinical Impact and Cosmetic Acceptability of Chlorhexidine-enriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study.

Abstract

AIMS:

Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed to evaluate the efficacy of two different pharmaceutical forms [toothpaste (TP) and mouthwash (MW)] of a new product containing chlorhexidine, dexpanthenol, allantoin and bioadhesive excipient (CDAB) (Bexident® Gums Coadjuvant Treatment) on volunteers with PD. Their preferences, acceptability and cosmetic properties, as well as tooth discoloration, were also assessed.

MATERIALS AND METHODS:

Total 60 subjects showing mild-moderate symptoms of gingivitis were randomly assigned to two different groups: one receiving TP (n = 30) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS).

RESULTS:

All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP)/36.7% (MW)] and from mild to negative [increase = 56.7% (TP)/50.0% (MW)]. After treatment, all subjects reported to have healthier and/or less bleeding teeth (TP 9.0/9.4; MW 8.0/8.2) and would recommend the product (TP:100%/MW:96.6%) with no specific preference regarding its presentation. No change of teeth color was observed.

CONCLUSION:

Subjects with PD who received oral care with a new formulation of either chlorhexidine-containing TP or MW for 21 days, reported a significant improvement of their symptoms and resolution of the gingivitis with no associated tooth discoloration. Patients did not show a specific preference for any of the pharmaceutical presentations.

CLINICAL SIGNIFICANCE:

This new formulation of a chlorhexidine-containing product in both TP and MW forms resulted effective for PD treatment and well accepted by the patients.

• Authors: Vanessa R Magaz, Bárbara F Llovera, Miriam Martí, Aurora Garre
• Journal: The journal of contemporary dental practice (J Contemp Dent Pract) Vol. 19 Issue 11 Pg. 1295-1300 (Nov 01 2018) ISSN: 1526-3711 [Electronic] India
• PMID: 30602630 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Mouthwashes
• Toothpastes
• Chlorhexidine

Topics

• Adolescent
• Adult
• Aged
• Chlorhexidine (administration & dosage, adverse effects)
• Female
• Gingivitis (drug therapy)
• Humans
• Male
• Middle Aged
• Mouthwashes (administration & dosage, chemistry)
• Patient Satisfaction
• Periodontal Diseases (drug therapy, psychology)
• Tooth Discoloration
• Toothpastes (administration & dosage, chemistry)
• Treatment Outcome
• Young Adult