Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease.

Abstract

BACKGROUND:

The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD).

METHODS:

This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan. The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements.

RESULTS:

Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, and TIMP-1 and ELF scores. The patients' serum concentrations of GDF-15, CCL2, HA, and TIMP-1 (but not PIIINP) were positively correlated with each other. Among them, serum GDF-15 most efficiently distinguished patients with IgG4-RD from healthy controls. Serum GDF-15 was not associated with the IgG4-RD RI score or the number of organ involvements but was independently associated with the presence of retroperitoneal fibrosis and with parotid gland involvement.

CONCLUSIONS:

We observed increased serological surrogate outcome measures of fibrosis in IgG4-RD. GDF-15 may precisely reflect the fibrotic degree in patients with IgG4-RD.

• Authors: Shin-Ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi, Atsushi Kawakami
• Journal: Arthritis research & therapy (Arthritis Res Ther) Vol. 20 Issue 1 Pg. 277 (12 14 2018) ISSN: 1478-6362 [Electronic] England
• PMID: 30547825 (Publication Type: Journal Article, Multicenter Study, Observational Study)

Chemical References

• Biomarkers
• CCL2 protein, human
• Chemokine CCL2
• GDF15 protein, human
• Growth Differentiation Factor 15
• Peptide Fragments
• Procollagen
• Tissue Inhibitor of Metalloproteinase-1
• procollagen Type III-N-terminal peptide
• Hyaluronic Acid

Topics

• Aged
• Biomarkers (blood)
• Chemokine CCL2 (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Growth Differentiation Factor 15 (blood)
• Humans
• Hyaluronic Acid (blood)
• Immunoglobulin G4-Related Disease (blood, pathology)
• Liver Cirrhosis (blood, pathology)
• Male
• Middle Aged
• Peptide Fragments (blood)
• Procollagen (blood)
• Retrospective Studies
• Tissue Inhibitor of Metalloproteinase-1 (blood)