Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.

Abstract

The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of polysaccharides on the granulopoietic lineage cells is comparable with that of recombinant CSF Neupogen.

• Authors: E A Safonova, K A Lopatina, T G Razina, E P Zueva, E P Fedorova, A M Gur'ev, M V Belousov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 166 Issue 2 Pg. 197-200 (Dec 2018) ISSN: 1573-8221 [Electronic] United States
• PMID: 30488221 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Hematologic Agents
• Plant Extracts
• Polysaccharides
• Paclitaxel
• Filgrastim
• Cisplatin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Carcinoma, Lewis Lung (drug therapy, immunology, pathology)
• Cisplatin (pharmacology)
• Female
• Filgrastim (pharmacology)
• Granulocytes (drug effects, immunology, pathology)
• Hematologic Agents (pharmacology)
• Leukocyte Count
• Mice
• Mice, Inbred C57BL
• Paclitaxel (pharmacology)
• Plant Extracts (chemistry)
• Polysaccharides (isolation & purification, pharmacology)
• Treatment Outcome
• Tumor Burden (drug effects)
• Tussilago (chemistry)