Treating chancroid with enoxacin.

Abstract

Increasing resistance of Haemophilus ducreyi to antimicrobials necessitates further trials of new antimicrobial agents for treating chancroid. Enoxacin has excellent in vitro activity against H ducreyi, and a randomised clinical trial of three doses of enoxacin 400 mg at intervals of 12 hours compared with a single dose of trimethoprim/sulphametrole (TMP/SMT) 640/3200 mg was therefore conducted. Of 169 men enrolled in the study, 86 received enoxacin and 83 received TMP/SMT. Ulcers were improved or cured in 65/73 men treated with enoxacin and 57/70 men treated with TMP/SMT. This difference was not significant. At 72 hours after treatment, H ducreyi was eradicated from ulcers of 72/77 men treated with enoxacin and of 67/74 of those treated with TMP/SMT. Patients with buboes responded equally well to both treatments. Of 100 H ducreyi strains tested, all were susceptible to both 0.25 mg/l enoxacin and the combination of 0.25 mg/l TMP and 5 mg/l SMT. Although most men treated with either regimen were cured, neither regimen appeared to be the optimum treatment for chancroid. This study shows the efficacy of enoxacin for a soft tissue infection caused by Gram negative organisms.

• Authors: W Naamara, D Y Kunimoto, L J D'Costa, J O Ndinya-Achola, H Nsanze, A R Ronald, F A Plummer
• Journal: Genitourinary medicine (Genitourin Med) Vol. 64 Issue 3 Pg. 189-92 (Jun 1988) ISSN: 0266-4348 [Print] England
• PMID: 3044978 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Naphthyridines
• Sulfanilamides
• Enoxacin
• Trimethoprim
• sulfametrole

Topics

• Adolescent
• Adult
• Anti-Infective Agents (therapeutic use)
• Chancroid (drug therapy)
• Clinical Trials as Topic
• Drug Therapy, Combination
• Enoxacin
• Humans
• Male
• Middle Aged
• Naphthyridines (therapeutic use)
• Random Allocation
• Sulfanilamides (therapeutic use)
• Trimethoprim (therapeutic use)