Trimethoprim (Proloprim)

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

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Networked: 1631 relevant articles (161 outcomes, 163 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kahlmeter, Gunnar: 3 articles (12/2015 - 07/2008)
2.	Kamya, Moses R: 3 articles (01/2012 - 01/2009)
3.	Dorsey, Grant: 3 articles (01/2012 - 01/2009)
4.	Queener, Sherry F: 3 articles (10/2011 - 04/2003)
5.	Dunstan, Frank: 3 articles (03/2009 - 09/2006)
6.	Hillier, Sharon: 3 articles (03/2009 - 09/2006)
7.	Palmer, Stephen: 3 articles (03/2009 - 09/2006)
8.	Phillips, G: 3 articles (05/2004 - 02/2000)
9.	Yasukawa, Masaki: 2 articles (07/2015 - 06/2009)
10.	Camillo, Giovana: 2 articles (02/2015 - 11/2014)

Related Diseases

1.	Infection 04/01/2009 - "However, several eukaryotic pathogenic organisms are resistant to trimethoprim, preventing its effective use as a therapeutic for those infections. " 06/01/1987 - "It is suitable for other pharmacokinetic studies involving trimethoprim but not its metabolites, and also for clinical assay of trimethoprim in situations where high levels of the antibiotic are necessary to combat resistant organisms and in serious infections by opportunistic organisms such as Pneumocystis carinii." 08/01/1981 - "Ninety-six elderly patients (mean age 80 years) with acute urinary infections were treated in a single-blind trial, with either one 200 mg dose of trimethoprim or 200 mg b.d. " 11/01/1969 - "Bacteriological, pharmacological and clinical studies with trimethoprim-sulphonamide combinations with particular reference to the treatment of urinary infections." 03/01/1969 - " studies showed that many bacteria causing urinary infections in hospital were sensitive to trimethoprim, and the therapeutic results could have been largely predicted from a knowledge of the in-vitro sensitivity tests to trimethoprim alone. "
2.	Urinary Tract Infections (Urinary Tract Infection) 04/11/1980 - "Since diabetics frequently suffer from urinary tract infections which can be successfully treated with a combination of sulphonamide derivatives and the bacteriocide trimethoprim, the question of possible interactions between such agents and diabetic therapy is of interest. " 06/01/1991 - "The efficacy of single dose treatment with trimethoprim compared to a 5-day course with the same drug was investigated in 100 children, 3-12 years, with isolated episodes of symptomatic non-febrile urinary tract infection. " 06/01/2001 - "The objective of this study was to evaluate the association between exposure to community-prescribed trimethoprim and other risk factors in subjects and subsequent trimethoprim-resistant urinary tract infection. " 02/01/1988 - "In the first study to assess the effect of trimethoprim in the treatment of acute urinary tract infections in children, we compared it with sulphisoxazole. " 03/01/1981 - "Studies concerning the treatment of urinary tract infections with trimethoprim alone are reviewed and results of the treatment of acute urinary tract infection with a single dose of trimethoprim at St Radboud Hospital are presented."
3.	Pneumonia (Pneumonitis) 04/01/1996 - "carinii pneumonitis without trimethoprim." 10/01/1984 - "A double-blind comparative study of trimethoprim versus trimethoprim-sulphamethaxazole combination in pneumonia." 01/01/2008 - "Preventive effect of sulfamethoxasole-trimethoprim on Pneumocystis jiroveci pneumonia in patients with interstitial pneumonia." 01/01/1983 - "Two fixed trimethoprim-sulfonamide combinations were compared in a clinical trial for their effectiveness and safety in the treatment of patients with acute lower respiratory tract infections (pneumonia, bronchopenumonia, purulent tracheobronchitis, ect.). " 02/01/1990 - "He suffered from pneumonia with marked improvement on sulfamethoxazole-Trimethoprim. "
4.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 11/01/2010 - "CT of the chest showed diffuse ground-glass bilateral opacities, and we immediately started a treatment with trimethoprim-sulfamethozazole and corticosteroid for the possibility of pneumocystis pneumonia. " 05/01/2005 - "Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). " 08/01/1997 - "A population pharmacokinetic model of trimethoprim in patients with pneumocystis pneumonia, made with parametric and nonparametric methods." 08/01/1991 - "Thirty-seven children were prescribed trimethoprim-sulfametoxazole as a prophylaxis for Pneumocystis carinii pneumonia.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1988 - "Two patients developed Pneumocystis carinii pneumonia, which was treated successfully in one patient with intravenous sulphadimidine and trimethoprim. "
5.	Typhoid Fever (Typhoid) 01/01/1985 - "It is therefore our opinion that treatment of typhoid fever with a sulfa-trimethoprim combination is both effective and safe." 06/01/1987 - "Trimethoprim in enteric fever." 08/01/1986 - "Trimethoprim alone is a suitable agent for the treatment of enteric fever." 08/01/1986 - "Trimethoprim in enteric fever." 01/31/1981 - "Trimethoprim in enteric fever."

Related Drugs and Biologics

1.	Sulfamethoxazole
2.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
3.	Ampicillin (Omnipen)
4.	Thymidine Monophosphate (TMP)
5.	Sulfadiazine (Sulphadiazine)
6.	Rifampin (Rifampicin)
7.	Dapsone
8.	Ciprofloxacin (Cipro)
9.	Chloramphenicol (Chloromycetin)
10.	Tetracycline (Achromycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Chemoprevention
4.	Oral Administration
5.	Prostatectomy (Retropubic Prostatectomy)