A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction.

Abstract

Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR-induced insulin sensitivity and improved insulin resistance.

• Authors: Habib Yaribeygi, Stephen L Atkin, Majid Ramezani, Amirhossein Sahebkar
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 6 Pg. 8436-8442 (06 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30426486 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Wiley Periodicals, Inc.

Topics

• Caloric Restriction
• Diabetes Mellitus (diet therapy, genetics, pathology)
• Diabetes Mellitus, Type 2 (diet therapy, genetics, pathology)
• Humans
• Insulin Resistance (genetics)
• Life Style
• Obesity (complications, genetics, pathology)