Oral ulcer healing and anti-Candida efficacy of an alcohol-free chitosan-curcumin mouthwash.

Abstract

OBJECTIVE:

The purpose of this study was to investigate oral ulcer healing and anti-Candida efficacy of an alcohol-free 0.1% chitosan-curcumin mouthwash.

MATERIALS AND METHODS:

A buccal mucosal ulcer was induced in hamster by topical application of acetic acid. The test mouthwash was applied to the ulcer twice a day for 7 consecutive days beginning on the fourth day after the ulcer induction. The anti-Candida efficacy of the mouthwash was determined against both free floating and biofilm forms of Candida albicans.

RESULTS:

The mouthwash significantly decreased the ulcer severity with a better ulcer healing efficacy than that of a standard benzydamine mouthwash. The mouthwash also exerted a comparable anti-Candida efficacy to a standard chlorhexidine mouthwash.

CONCLUSIONS:

An alcohol-free 0.1% chitosan-curcumin mouthwash may serve as a safe and potential topical alternative agent in the management of oral inflammatory ulcer and of candidiasis.

• Authors: S Mahattanadul, M W Mustafa, S Kuadkaew, S Pattharachayakul, S Ungphaiboon, K Sawanyawisuth
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 22 Issue 20 Pg. 7020-7023 (10 2018) ISSN: 2284-0729 [Electronic] Italy
• PMID: 30402869 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mouthwashes
• Chitosan
• Curcumin
• Chlorhexidine

Topics

• Animals
• Biofilms (drug effects)
• Candida (drug effects)
• Candida albicans (drug effects)
• Chitosan (administration & dosage)
• Chlorhexidine (pharmacology)
• Cricetinae
• Curcumin (administration & dosage)
• Female
• Male
• Mouthwashes (administration & dosage)
• Oral Ulcer (drug therapy)
• Wound Healing (drug effects)