Abstract | AIMS: To assess the expression of epithelial-mesenchymal transition (EMT) regulators in follicular thyroid tumours. METHODS AND RESULTS: The expression of E-cadherin (E-CAD) and transcription factors TWIST, SLUG and SNAIL in follicular thyroid tumours was examined by immunohistochemistry in tissue samples, including 18 follicular adenomas (FA), 12 minimally invasive follicular thyroid carcinomas (MI- FTC), 16 widely invasive follicular thyroid carcinomas (WI- FTC), 10 poorly differentiated follicular thyroid carcinomas ( PDTC) and six anaplastic thyroid carcinomas (ATC). Metastatic tumour tissues from six of these cases were also examined. The results showed an increasing expression trend of EMT regulators in a panel of follicular tumour cases with a spectrum of morphological subtypes from low- to high-risk malignancy. The expression of EMT regulators was higher in the WI- FTC, PDTC and ATC groups but focal and lower in the FA and MI- FTC groups. Different expression intensity of E-CAD and EMT regulators at the tumour centre part and the invasive front (IF) was observed. The loss of E-CAD and expression of EMT regulators was significantly correlated with distant metastasis and vascular invasion (VI) in the well-differentiated follicular carcinoma (WD- FTC), and six tumours of metastatic sites also showed variables positive for EMT regulators. The disease-free survival analysis showed an apparent relationship between the expression of EMT regulators and the tumour disease-free outcomes in WD- FTC. CONCLUSIONS:
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Authors | Jianghua Wu, Yanhui Zhang, Runfen Cheng, Wenchen Gong, TingTing Ding, Qiongli Zhai, Yong Wang, Bin Meng, Baocun Sun |
Journal | Histopathology
(Histopathology)
Vol. 74
Issue 5
Pg. 780-791
(Apr 2019)
ISSN: 1365-2559 [Electronic] England |
PMID | 30368884
(Publication Type: Journal Article)
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Copyright | © 2018 John Wiley & Sons Ltd. |
Chemical References |
- Antigens, CD
- Biomarkers, Tumor
- CDH1 protein, human
- Cadherins
- Nuclear Proteins
- SNAI1 protein, human
- Snail Family Transcription Factors
- TWIST1 protein, human
- Twist-Related Protein 1
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Topics |
- Adenocarcinoma, Follicular
(metabolism, secondary)
- Adult
- Aged
- Antigens, CD
(biosynthesis)
- Biomarkers, Tumor
(biosynthesis)
- Cadherins
(biosynthesis)
- Disease-Free Survival
- Epithelial-Mesenchymal Transition
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Nuclear Proteins
(biosynthesis)
- Snail Family Transcription Factors
(biosynthesis)
- Thyroid Neoplasms
(metabolism, pathology)
- Twist-Related Protein 1
(biosynthesis)
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