Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum.

Abstract

Dipylidium caninum is a cosmopolitan cestode infecting dogs, cats, and humans. Praziquantel is a highly effective cestocidal drug and resistance in adult cestodes has not been reported. From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of D. caninum were clinically resistant to praziquantel and could not be resolved despite increasing the dose, frequency, and duration of treatment. Resistant isolates were identified and characterized by sequencing the 28S, 12S, and voltage-gated calcium channel beta subunit genes. Cases were only resolved following treatment with nitroscanate or a compounded pyrantel/praziquantel/oxantel product. Clinicians should be aware of this alarming development as treatment options for cestodes are limited in both human and veterinary medicine.

• Authors: Jeba Jesudoss Chelladurai, Tsegabirhan Kifleyohannes, Janelle Scott, Matthew T Brewer
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 99 Issue 5 Pg. 1201-1205 (11 2018) ISSN: 1476-1645 [Electronic] United States
• PMID: 30226153 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anthelmintics
• Phenyl Ethers
• RNA, Ribosomal
• RNA, Ribosomal, 28S
• RNA, ribosomal, 12S
• Thiocyanates
• epsiprantel
• Pyrantel
• Praziquantel
• oxantel
• nitroscanate

Topics

• Animals
• Anthelmintics (pharmacology, therapeutic use)
• Cestoda (drug effects, genetics)
• Cestode Infections (drug therapy, veterinary)
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Drug Resistance, Multiple
• Feces (parasitology)
• Phenyl Ethers (therapeutic use)
• Praziquantel (analogs & derivatives, pharmacology, therapeutic use)
• Pyrantel (analogs & derivatives, therapeutic use)
• RNA, Ribosomal (genetics)
• RNA, Ribosomal, 28S (genetics)
• Thiocyanates (therapeutic use)
• Treatment Outcome