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oxantel

oxyphenyl analog of pyrantel; RN given refers to (E)-isomer; synonym CP-14,445-16 refers to oxantel pamoate

Also Known As:

1,4,5,6-tetrahydro-2-(3-hydroxy styryl)-1-methylpyrimidine; CP 14,445; CP-14,445; oxantel monohydrochloride, (E)-isomer; oxantel tartrate; oxantel tartrate (1:1), (R-(R*,R*))-isomer

Networked: 17 relevant articles (9 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hoffmann, Brigitte: 1 article (01/2014)
2.	O'Brien-Simpson, Neil: 1 article (01/2014)
3.	Catmull, Deanne: 1 article (01/2014)
4.	Walsh, Katrina: 1 article (01/2014)
5.	D'Cruze, Tanya: 1 article (01/2014)
6.	Liu, Sze Wei: 1 article (01/2014)
7.	Dashper, Stuart: 1 article (01/2014)
8.	Reynolds, Eric: 1 article (01/2014)
9.	Zhu, Ying: 1 article (01/2014)
10.	Mitchell, Helen: 1 article (01/2014)

Related Diseases

1.	Infection 08/01/2004 - "Oxantel is a cholinergic anthelmintic that was first introduced for the treatment of whipworm, Trichuris, infections in children. " 01/01/1978 - "Oxantel, the most recent drug shown to be effective against Trichuris is discussed, as is oxantel-pyrantel which promises to be effective against mixed helminthic infections." 11/01/2002 - "Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5% vs. 23.3%, P < 0.01), though the reductions in egg counts did not differ significantly and were more than 80%. " 12/01/1979 - "[Treatment of mixed helminthic infection with oxantel-pyrantel pamoate (author's transl)]." 11/01/2002 - "Both mebendazole and pyrantel-oxantel were very effective in eliminating Ascaris lumbricoides infection, inducing cure rates of more than 96% and reducing the mean egg counts by more than 95%. "
2.	Trichuriasis 07/01/1976 - "It is concluded that oxantel is a safe and effective anthelmintic for severe clinical trichuriasis." 01/01/1978 - "For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested." 04/01/1982 - "[Massive trichocephaliasis and other helminthiasis in children and its treatment with pyrantel pamoate/oxantel]." 01/01/1978 - "In a pilot study in 17 children, oxantel-pyrantel as one single dose of 10 to 20mg/kg of each, gave good results in ascariasis but poor cure rates in both trichuriasis and necatoriasis. " 01/01/1978 - "204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. "
3.	Nematode Infections 01/01/1978 - "The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection." 11/01/2002 - "Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections." 09/01/1980 - "Intestinal nematode infections and efficacy study of oxantel-pyrantel pamoate among plantation workers." 01/01/1978 - "Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections." 11/01/2002 - "A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. "
4.	Ascariasis 01/01/1978 - "The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. " 01/01/1978 - "In a pilot study in 17 children, oxantel-pyrantel as one single dose of 10 to 20mg/kg of each, gave good results in ascariasis but poor cure rates in both trichuriasis and necatoriasis. " 01/01/1978 - "204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. " 01/01/1978 - "32 elementary school children were treated for multiple intestinal helminthiasis (ascariasis, trichuriasis and hookworm infections) with a combination of the pamoate salts of oxantel and pyrantel in a dose of 15 to 20mg/kg body weight of each in 1 daily dose for 3 consecutive days. "
5.	Necatoriasis 01/01/1978 - "In a pilot study in 17 children, oxantel-pyrantel as one single dose of 10 to 20mg/kg of each, gave good results in ascariasis but poor cure rates in both trichuriasis and necatoriasis. "

Related Drugs and Biologics

1.	Pyrantel
2.	Mebendazole (Vermin)
3.	quantrel
4.	Immunoglobulin E (IgE)
5.	Tablets
6.	Pyrantel Pamoate (Pyrantel Embonate)
7.	Salts
8.	Praziquantel (Biltricide)
9.	Intestinal helminthiasis