Meropenem-vaborbactam for the treatment of complicated urinary tract infections including acute pyelonephritis.

Abstract

INTRODUCTION:

Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carbapenemases (KPC), in addition to other class A and class C beta-lactamases. The US Food and Drug Administration has recently approved meropenem-vaborbactam for the treatment of adult patients with complicated urinary tract infections including acute pyelonephritis. Areas covered: A PubMed search was performed to gather the most current and relevant articles regarding meropenem-vaborbactam. In this review the authors discuss the chemistry, mechanism of action, pharmacokinetics, pharmacodynamics, antimicrobial spectrum, and efficacy and safety of meropenem-vaborbactam for the treatment of complicated urinary tract infections including acute pyelonephritis Expert opinion: Although meropenem-vaborbactam is approved for treatment for complicated urinary tract infections including acute pyelonephritis, it is unlikely, at this point, to be utilized widely beyond cases that are caused by KPC-producing Enterobacteriaceae. It may also be a potential treatment option for complicated urinary tract infections caused by KPC-producing Enterobacteriaceae that are resistant to ceftazidime-avibactam. Long-term safety data with this novel beta-lactamase inhibitor is still needed although early data suggests that it will be safe and well tolerated.

• Authors: Gary Wu, Eunah Cheon
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 19 Issue 13 Pg. 1495-1502 (Sep 2018) ISSN: 1744-7666 [Electronic] England
• PMID: 30160990 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Azabicyclo Compounds
• Boronic Acids
• Drug Combinations
• Thienamycins
• avibactam, ceftazidime drug combination
• vaborbactam
• Ceftazidime
• Meropenem

Topics

• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Azabicyclo Compounds (administration & dosage)
• Boronic Acids (administration & dosage)
• Ceftazidime (administration & dosage)
• Drug Combinations
• Enterobacteriaceae (drug effects)
• Humans
• Klebsiella pneumoniae (drug effects)
• Meropenem
• Pyelonephritis (drug therapy)
• Thienamycins (administration & dosage)
• Urinary Tract Infections (drug therapy)