Oxycodone versus sufentanil in adult patient-controlled intravenous analgesia after abdominal surgery: A prospective, randomized, double-blinded, multiple-center clinical trial.
Abstract | BACKGROUND: METHODS: Adult patients undergoing elective abdominal surgery were randomly allocated into oxycodone and sufentanil groups according to the randomization sequence. Study personnel, health-care team members, and patients were masked to the group assignment throughout the study period. Oxycodone (0.1 mg/kg for endoscopy; 0.15 mg/kg for laparotomy) or sufentanil (0.1 μg/kg for endoscopy; 0.15 μg/kg for laparotomy) was administrated at the end of surgeries. Postoperative pain was controlled using PCIA. Bolus dose was 2 mg and 2 μg for oxycodone and sufentanil group, respectively. The lockout time was 5 minutes for all patients, and there was no background infusion for oxycodone group, whereas 0.02 μg/kg/h background infusion was administrated in sufentanil group. The primary outcomes were the total analgesic doses in PCIA, effective bolus times, the length of first bolus since patients returning to ward from postanesthesia care unit (PACU), rescue analgesic rate in PACU, numeric rating scales, functional activity scores, and patients' satisfaction scores. RESULTS: DISCUSSION:
|
Authors | Lichun Han, Yuqiang Su, Hongfei Xiong, Xiaoli Niu, Shajie Dang, Keqin Du, Quan Li, Jing Liu, Peng Zhang, Siyuan Li |
Journal | Medicine
(Medicine (Baltimore))
Vol. 97
Issue 31
Pg. e11552
(Aug 2018)
ISSN: 1536-5964 [Electronic] United States |
PMID | 30075523
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- Analgesics, Opioid
- Sufentanil
- Oxycodone
|
Topics |
- Adult
- Aged
- Analgesia, Patient-Controlled
- Analgesics, Opioid
(administration & dosage, adverse effects, therapeutic use)
- Anesthesia Recovery Period
- Double-Blind Method
- Endoscopy
- Female
- Humans
- Laparoscopy
- Male
- Middle Aged
- Oxycodone
(administration & dosage, adverse effects, therapeutic use)
- Pain, Postoperative
(drug therapy)
- Prospective Studies
- Sufentanil
(administration & dosage, adverse effects, therapeutic use)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|