Extracellular Matrix-receptor Interaction Signaling Genes Associated with Inferior Breast Cancer Survival.

Abstract

BACKGROUND/AIM:

Breast cancer is a common type of cancer in women, and metastasis frequently leads to therapy failure. Using next-generation sequencing (NGS), we aspired to identify the optimal differentially expressed genes (DEGs) for use as prognostic biomarkers for breast cancer.

MATERIALS AND METHODS:

NGS was used to determine transcriptome profiles in breast cancer tissues and their corresponding adjacent normal tissues from three patients with breast cancer.

RESULTS:

Herein, 15 DEGs (fold change >4 and <0.25) involved in extracellular matrix (ECM)-receptor interaction signaling were identified through NGS. Among them, our data indicated that high HMMR expression levels were correlated with a poor pathological stage (p<0.001) and large tumor size (p<0.001), whereas high COL6A6 and Reelin (RELN) expression levels were significantly correlated with an early pathological stage (COL6A6: p=0.003 and RELN: p<0.001). Multivariate analysis revealed that high HMMR and SDC1 expression levels were significantly correlated with poor overall survival (OS; HMMR: adjusted hazard ratio [aHR] 1.93, 95% confidence interval [CI]=1.10-3.41, p=0.023; SDC1: [aHR] 2.47, 95%CI=1.28-4.77, p=0.007) for breast cancer. Combined, the effects of HMMR and SDC1 showed a significant correlation with poor OS for patients with breast cancer (high expression for both HMMR and SDC1: [aHR] 3.29, 95%CI=1.52-7.12, p=0.003).

CONCLUSION:

These findings suggest that HMMR and SDC1 involved in the ECM-receptor interaction signaling pathway could act as effective independent prognostic biomarkers for breast ductal carcinoma.

• Authors: Ming-Hsin Yeh, Yau-Jin Tzeng, Ting-Ying Fu, Jun-Jie You, Hong-Tai Chang, Luo-Ping Ger, Kuo-Wang Tsai
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 8 Pg. 4593-4605 (Aug 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 30061226 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• Cell Adhesion Molecules, Neuronal
• Collagen Type VI
• Extracellular Matrix Proteins
• Hyaluronan Receptors
• Nerve Tissue Proteins
• Receptors, Cell Surface
• Reelin Protein
• Syndecan-1
• extracellular matrix receptor
• hyaluronan-mediated motility receptor
• RELN protein, human
• Serine Endopeptidases

Topics

• Adult
• Biomarkers, Tumor (genetics)
• Breast (pathology)
• Breast Neoplasms (genetics, mortality, pathology)
• Cell Adhesion Molecules, Neuronal (genetics)
• Collagen Type VI (genetics)
• Extracellular Matrix Proteins (genetics)
• Female
• Humans
• Hyaluronan Receptors (genetics)
• Middle Aged
• Nerve Tissue Proteins (genetics)
• Prognosis
• Receptors, Cell Surface (genetics)
• Reelin Protein
• Serine Endopeptidases (genetics)
• Signal Transduction (genetics)
• Syndecan-1 (genetics)
• Transcriptome (genetics)