Mixed mold pulmonary infections in haematological cancer patients in a tertiary care cancer centre.

Abstract

There is a paucity of data regarding mixed mold pulmonary infections (MMPIs) in patients with haematological malignancies with or without haematopoietic stem cell transplantation (HSCT). We retrospectively studied 27 such patients (2005-2015) and compared them to patients with invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus. Factors associated with the diagnosis of MMPIs were significant corticosteroid use [20 (74%) vs 6 (22%), P < 0.001], sputum as the source specimen [13 (48%) vs 3 (11%), P = 0.003], younger age (median age: 58 vs 66 years, P = 0.006), and male sex [22 (81%) vs 13 (48%), P = 0.01]. Haematological cancers other than acute myeloid leukaemia (AML)/myelodysplastic syndromes (MDS) were less common in MMPIs than in IPA patients [AML/MDS: 6 (22%) vs 14 (52%), P = 0.04]. Only significant corticosteroid use [95% CI (2.7-42.7), P < 0.001], and sputum as the source specimen [95% (1.6-41.6), P = 0.012] were statistically significant as independently associated with increased risk of MMPIs diagnosis in multivariate analysis. Total mortality rate at day 42 postdiagnosis was comparable in both groups.

• Authors: Eleni E Magira, Ying Jiang, Minas Economides, Jeffrey Tarrand, Dimitrios P Kontoyiannis
• Journal: Mycoses (Mycoses) Vol. 61 Issue 11 Pg. 861-867 (Nov 2018) ISSN: 1439-0507 [Electronic] Germany
• PMID: 30015364 (Publication Type: Journal Article)
• Copyright: © 2018 Blackwell Verlag GmbH.

Topics

• Adolescent
• Adult
• Aged
• Aspergillus fumigatus (drug effects, genetics, isolation & purification, physiology)
• Female
• Hematologic Neoplasms (drug therapy, microbiology, surgery)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Invasive Pulmonary Aspergillosis (diagnosis, drug therapy, etiology, microbiology)
• Male
• Middle Aged
• Postoperative Complications (diagnosis, drug therapy, etiology, microbiology)
• Retrospective Studies
• Tertiary Healthcare (statistics & numerical data)
• Young Adult