New insight into GABAergic neurons in the hypothalamic feeding regulation.

Abstract

Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other GABAergic neurons act as an orexigenic. Here, we review the progress of studies on hypothalamic GABAergic neurons distributed in ARC, dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH). Three advanced technologies have been applied and greatly contributed to the recent progress. Optogenetic (and chemogenetic) approaches map input and output pathways of particular subpopulations of GABAergic neurons. In vivo Ca2+ imaging using GRIN lens and GCaMP can correlate the activity of GABAergic neuron subpopulations with feeding behavior. Single-cell RNA-seq approach clarifies precise transcriptional profiles of GABAergic neuron subpopulations. These approaches have shown diversity of GABAergic neurons and the subpopulation-dependent role in feeding regulation.

• Authors: Shigetomo Suyama, Toshihiko Yada
• Journal: The journal of physiological sciences : JPS (J Physiol Sci) Vol. 68 Issue 6 Pg. 717-722 (Nov 2018) ISSN: 1880-6562 [Electronic] Japan
• PMID: 30003408 (Publication Type: Journal Article, Review)

Chemical References

• AGRP protein, human
• Agouti-Related Protein
• Neuropeptide Y
• gamma-Aminobutyric Acid
• Pro-Opiomelanocortin

Topics

• Agouti-Related Protein (metabolism)
• Animals
• Appetite Regulation
• Eating
• Feeding Behavior
• GABAergic Neurons (metabolism)
• Humans
• Hypothalamus (cytology, metabolism)
• Neural Pathways (metabolism)
• Neuroanatomical Tract-Tracing Techniques
• Neuropeptide Y (metabolism)
• Optogenetics
• Pro-Opiomelanocortin (metabolism)
• Sequence Analysis, RNA
• Single-Cell Analysis
• Synaptic Transmission
• gamma-Aminobutyric Acid (metabolism)