Abstract | INTRODUCTION:
Chronic obstructive pulmonary disease ( COPD) management focuses on the alleviation of symptoms and prevention of exacerbations. Inhaled long acting bronchodilators and inhaled corticosteroids (ICS) are the main classes of treatment for COPD. Triple therapy with a long acting beta2-agonist (LABA), long acting muscarinic antagonist (LAMA), and ICS is commonly prescribed for symptomatic COPD patients experiencing regular exacerbations. Triple therapy is usually administered using separate inhalers; there is little clinical trial evidence of an effect on exacerbation prevention with this approach. Areas covered: This evaluation reviews the single inhaler extrafine combination containing beclometasone diproprionate (BDP), formoterol fumarate (FF), and glycopyrronium bromide (GB) which has been developed as a simplified triple regime. BDP/FF/GB significantly reduced exacerbation rates in three clinical trials (1-year duration) compared against LAMA monotherapy (20% exacerbation reduction), ICS/LABA combination (23% exacerbation reduction), and LAMA/LABA combination (15% exacerbation reduction). Expert opinion: The practical benefits of single inhaler triple therapy in the real world have not been studied. However, the robust clinical trial evidence that BDP/FF/GB reduces exacerbations compared to double combination treatments and LAMA monotherapy cements triple therapy positioning as an escalation step in COPD management pathways.
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Authors | Dave Singh |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 19
Issue 11
Pg. 1279-1287
(Aug 2018)
ISSN: 1744-7666 [Electronic] England |
PMID | 29985096
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-2 Receptor Agonists
- Beclomethasone
- Glycopyrrolate
- Formoterol Fumarate
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Topics |
- Administration, Inhalation
- Adrenergic beta-2 Receptor Agonists
(pharmacology, therapeutic use)
- Beclomethasone
(pharmacology, therapeutic use)
- Drug Therapy, Combination
(methods)
- Formoterol Fumarate
(pharmacology, therapeutic use)
- Glycopyrrolate
(pharmacology, therapeutic use)
- Humans
- Pulmonary Disease, Chronic Obstructive
(drug therapy, pathology)
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