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Fluorous interaction induced self-assembly of tobacco mosaic virus coat protein for cisplatin delivery.

Abstract
Tobacco mosaic virus coat protein was modified with a small molecular fluorous ponytail at specific sites, and self-assembled into spherical nanoparticles through fluorous interaction induced self-assembly. By loading the anti-cancer drug cisplatin through metal-ligand coordination, this spherical assembly with high stability has potential as a drug carrier.
AuthorsSijia Gao , Xiangxiang Liu , Zhaocheng Wang , Shidong Jiang , Man Wu , Ye Tian , Zhongwei Niu
JournalNanoscale (Nanoscale) Vol. 10 Issue 25 Pg. 11732-11736 (Jul 05 2018) ISSN: 2040-3372 [Electronic] England
PMID29911244 (Publication Type: Journal Article)
Chemical References
  • Capsid Proteins
  • Drug Carriers
  • H protein, Tobacco mosaic virus
  • Fluorine
  • Cisplatin
Topics
  • Capsid Proteins (chemistry)
  • Cisplatin (administration & dosage)
  • Drug Carriers (chemistry)
  • Fluorine (chemistry)
  • HeLa Cells
  • Humans
  • Nanoparticles (chemistry)

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