Dietary antioxidant intake and the risk of developing Barrett's oesophagus and oesophageal adenocarcinoma.

Abstract

BACKGROUND:

We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC).

METHODS:

A total of 24,068 well individuals completed 7-DFDs and donated blood. Vitamins C and E, carotenes, zinc and selenium intakes, and plasma vitamin C were measured. Participants were monitored for 15 years for BO and OAC. Hazard ratios (HRs) were estimated for: quintiles of intake and in participants younger and >=65 years at recruitment, the midpoint of BO peak prevalence.

RESULTS:

A total of 197 participants developed BO and 74 OAC. There were no significant associations between antioxidants and BO or OAC in the whole cohort or if >65 years at recruitment. In participants <65 years, for BO, there was an inverse trend across plasma vitamin C quintiles (trend HR = 0.82; 95% CI = 0.71-0.96, P = 0.01), OAC for plasma vitamin C (trend HR = 0.58; 95% CI = 0.37-0.92, P = 0.02) and for dietary vitamins C and E (trend HR = 0.71 95% CI = 0.51-0.99, P = 0.04 and trend HR = 0.70; 95% CI = 0.51-0.96; P = 0.03).

CONCLUSIONS:

Data supports a role for dietary antioxidants prevent BO and OAC, perhaps at the earlier stages of carcinogenesis.

• Authors: James H-E Kang, Robert Luben, Leo Alexandre, Andrew R Hart
• Journal: British journal of cancer (Br J Cancer) Vol. 118 Issue 12 Pg. 1658-1661 (06 2018) ISSN: 1532-1827 [Electronic] England
• PMID: 29780162 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Vitamin E
• Carotenoids
• Selenium
• Zinc
• Ascorbic Acid

Topics

• Adult
• Aged
• Antioxidants (administration & dosage)
• Ascorbic Acid (blood)
• Barrett Esophagus (blood, epidemiology)
• Carotenoids (blood)
• Cohort Studies
• Diet (statistics & numerical data)
• Diet Records
• England (epidemiology)
• Esophageal Neoplasms (blood, epidemiology)
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Selenium (blood)
• Vitamin E (blood)
• Zinc (blood)