The probable roles of valsartan in alleviating chronic obstructive pulmonary disease following co-exposure to cold stress and fine particulate matter.

Abstract

Angiotensin II (ANG II) might play an important role in the co-effects of cold stress and fine particulate matter (PM2.5) on chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate the roles of valsartan in alleviating COPD following co-exposure to cold stress and PM2.5. Both the two intervention factors are carried out upon COPD rats with the intervention of valsartan. Blockade of angiotensin receptor by valsartan decreases the levels of malondialdehyde in the normal temperature and tumor necrosis factor-α under cold stress significantly. When treated with valsartan and PM2.5 simultaneously, the expression of 8-hydroxy-2-deoxyguanosine, nuclear factor kappa B and heme oxygenase-1 decrease significantly in the group of cold stress. In conclusion, these results indicate that valsartan might relieve the co-effects of cold stress and PM2.5 on COPD rat lung to some degree.

• Authors: Jiangtao Liu, Lei Guo, Kai Zhang, Quanquan Song, Qiaozhen Wei, Qin Bian, Tingting Liang, Jingping Niu, Bin Luo
• Journal: Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 60 Pg. 230-236 (Jun 2018) ISSN: 1872-7077 [Electronic] Netherlands
• PMID: 29775776 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• NF-kappa B
• Particulate Matter
• Tumor Necrosis Factor-alpha
• Malondialdehyde
• Valsartan
• 8-Hydroxy-2'-Deoxyguanosine
• Heme Oxygenase-1
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Angiotensin II Type 1 Receptor Blockers (administration & dosage, pharmacology)
• Animals
• Cold Temperature (adverse effects)
• Deoxyguanosine (analogs & derivatives, metabolism)
• Disease Models, Animal
• Gene Expression Regulation (drug effects)
• Heme Oxygenase-1 (metabolism)
• Humans
• Male
• Malondialdehyde (metabolism)
• NF-kappa B (metabolism)
• Particulate Matter (toxicity)
• Pulmonary Disease, Chronic Obstructive (chemically induced, drug therapy, metabolism)
• Rats
• Tumor Necrosis Factor-alpha (metabolism)
• Valsartan (administration & dosage, pharmacology)