[Effect of compatibility of ginkgolide A, ginkgolide B and ginkgolide K].

Abstract

To investigate the best active compatibility of ginkgolide A, B and K (GA，GB，GK). The effects of GA, GB, GK alone, combinations of each two of them, and combinations of these three components on platelet-activating factor (PAF)-induced platelet aggregation activity and rat cerebral ischemia reperfusion model (tMCAO) were compared in this study. Different compatibilities of GA, GB and GK could significantly reduce the maximum aggregation rate of PAF-induced platelet aggregation, and the effect was most obvious in combination of the three. Different compatibilities of GA, GB and GK could alleviate the neural function, cerebral infarction volume and cerebral edema in the tMCAO model of rats to different degrees, and the effect of combinations of the three was stronger than those of combinations of two and single use. The combination of all of GA, GB and GK had the strongest effect on nerve injury caused by anti-platelet aggregation in tMCAO rats.

• Authors: Hong Zhang, Yan-Ping Luo, Ze-Yu Cao, Xin-Zhuang Zhang, Liang Cao, Zhen-Zhong Wang, Wei Xiao
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 43 Issue 7 Pg. 1410-1415 (Apr 2018) ISSN: 1001-5302 [Print] China
• PMID: 29728030 (Publication Type: Journal Article)
• Copyright: Copyright© by the Chinese Pharmaceutical Association.

Chemical References

• Ginkgolides
• Lactones
• Platelet Activating Factor
• ginkgolide K
• ginkgolide B
• ginkgolide A

Topics

• Animals
• Brain Ischemia (drug therapy)
• Ginkgolides (pharmacology)
• Lactones (pharmacology)
• Platelet Activating Factor (metabolism)
• Platelet Aggregation
• Rats
• Reperfusion Injury (drug therapy)