ginkgolide A

Also Known As:

BN 52020; BN-52020; BN52020; 6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b-dihydroxy-5-methyl-, (3aR,4aR,4bR,5S,7aS,8aS,9R,11S, 11aS)-

Networked: 37 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Ginkgolides: 92
        ginkgolide A: 37
- Lactones: 1549
  - ginkgolide A: 37

Experts

1.	Mohandas, Sundhar: 2 articles (09/2020 - 01/2020)
2.	Vairappan, Balasubramaniyan: 2 articles (09/2020 - 01/2020)
3.	Xiao, Wei: 2 articles (03/2020 - 01/2019)
4.	Shah, Zahoor A: 2 articles (01/2015 - 04/2012)
5.	Chen, Changyi: 2 articles (11/2011 - 10/2006)
6.	Lin, Peter H: 2 articles (11/2011 - 10/2006)
7.	Yao, Qizhi: 2 articles (11/2011 - 10/2006)
8.	Slomiany, Amalia: 2 articles (08/2003 - 06/2003)
9.	Slomiany, Bronislaw L: 2 articles (08/2003 - 06/2003)
10.	Hua, Dongxu: 1 article (05/2022)

Related Diseases

1.	Ischemia 01/01/2022 - "Most studies have focused on the protective effects of ginkgolide A against ischemia/reperfusion-induced cardiomyopathy and injury of the brain, liver, and other organs, but there are few reports about the protection of lung tissues. " 02/01/1993 - "The neuroprotective effects of the platelet-activating factor (PAF) antagonists BN 52020 and BN 52021 were determined in a temperature-controlled model of transient forebrain ischemia in the rat (occlusion of both common carotid arteries combined with lowering of the mean arterial blood pressure to 40 mm Hg for 10 min). " 01/01/2015 - "Recent studies show anxiolytic properties of ginkgolide A, migraine with aura treatment by ginkgolide B, a reduction in ischemia-induced glutamate excitotoxicity by bilobalide, and an alternative antihypertensive property of quercetin, among others. " 02/01/1995 - "These drugs were administrated as followed: MK-801 (a noncompetitive inhibitor of NMDA channel), 0.8 mg/kg i.p., 30 min before ischemia, and 5 min after the insult; L-NAME (competitive inhibitor of NO synthase), 10 mg/kg i.p., 30 min before ischemia, and 5 mg/kg, 5 min after ischemia; BN52020 and BN52021 (inhibitors of platelet-activating factor: PAF receptors) were administered as a suspension in 5% ethanol in water by oral route, 10 mg/kg for 3 days before ischemia. "
2.	Inflammation (Inflammations) 01/01/2016 - "Inhibition of NF-κB activity by NF-κB-specific suppressor IκBα is one of the potential mechanisms of Ginkgolide A against CCl4-induced liver inflammation. " 01/01/2016 - "siRNA-mediated decrease of PXR expression significantly reduced the efficacy of Ginkgolide A in treating CCl4-induced inflammation in mice. " 01/01/2016 - "PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice." 05/15/2022 - "This study aims to explore whether ginkgolide A (GA) could improve cardiac dysfunction of MI mice, and whether it could alleviate cardiac remodeling via binding to matrix metalloproteinase-9 (MMP9) to attenuate inflammation. " 09/15/2020 - "We previously showed that Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ). "
3.	Cardiovascular Diseases (Cardiovascular Disease) 04/10/2017 - "Ginkgolide A (GA) is a natural compound isolated from Ginkgo biloba and has been used to treat cardiovascular diseases and diabetic vascular complications. " 04/01/2015 - "Ginkgolide A (GA), a major compound from Ginkgo biloba extract, is widely used for the treatment of cardiovascular diseases and diabetic vascular complications. " 10/01/2006 - "This study underscores potential clinical benefits and applications of ginkgolide A in controlling homocysteine-associated vascular injury and cardiovascular disease." 01/21/2005 - "Ginkgo biloba extract (GBE), a valuable natural product for cerebral and cardiovascular diseases, is mainly composed of two classes of constituents: terpene lactones (e.g., ginkgolide A and B, bilobalide) and flavone glycosides (e.g., quercetin and kaempferol). "
4.	Cardiomyopathies (Cardiomyopathy) 01/01/2022 - "Most studies have focused on the protective effects of ginkgolide A against ischemia/reperfusion-induced cardiomyopathy and injury of the brain, liver, and other organs, but there are few reports about the protection of lung tissues. " 08/01/2023 - "Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy."
5.	Diabetic Angiopathies (Diabetic Angiopathy) 04/10/2017 - "Ginkgolide A (GA) is a natural compound isolated from Ginkgo biloba and has been used to treat cardiovascular diseases and diabetic vascular complications. " 04/01/2015 - "Ginkgolide A (GA), a major compound from Ginkgo biloba extract, is widely used for the treatment of cardiovascular diseases and diabetic vascular complications. "

Related Drugs and Biologics

1.	Ginkgo biloba extract (Rokan)
2.	Antioxidants
3.	Small Interfering RNA (siRNA)
4.	Hydrogen Peroxide (Hydroperoxide)
5.	Carbon Tetrachloride (Tetrachloromethane)
6.	Ascorbic Acid (Vitamin C)
7.	ginkgolide B
8.	bilobalide
9.	Ginkgolides
10.	Quercetin