Target challenging-cancer drug delivery to gastric cancer tissues with a fucose graft epigallocatechin-3-gallate-gold particles nanocomposite approach.

Abstract

Inhibiting component of therapy with (-)-epigallocatechin-3-gallate (EGCG) is low bioavailability of fresh tea polyphenols that outcome from insecurity under stomach related circumstances, insufficient transcellular transport. As needs are, fucose- carboxymethyl chitosan (FU-CMC) graft EGCG with gold nanoparticles (GNPs) (FU-CMC-EGCG-GNPs) nanocomposites were prepared and managed peritumorally to assess their anticancer action. The physicochemical properties of as-prepared nanocomposite were evaluated by FTIR spectroscopy, UV-visible absorption spectra, XRD, FESEM-EDX and HRTEM-SAD. Additionally, the viability and cell uptake assays revealed that the as-prepared nanocomposite successfully repressed the propagation of gastric tumor cells. In vivo anticancer treatment of FU-CMC-EGCG-GNPs nanocomposites showed more anticancer action contrasted with pure EGCG. Immuno-histological investigations established a superior numeral of apoptotic tissues in the as-prepared FU-CMC-EGCG-GNPs nanocomposites contrasted with pure EGCG. Overall, the as-prepared FU-CMC-EGCG-GNPs nanocomposite affords a proficient medicine delivery stage for chemotherapy.

• Authors: Xiaoming Yuan, Yan He, Guangrong Zhou, Xiangwei Li, Aiwen Feng, Weiwei Zheng
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 183 Pg. 147-153 (Jun 2018) ISSN: 1873-2682 [Electronic] Switzerland
• PMID: 29705507 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Drug Carriers
• carboxymethyl-chitosan
• Fucose
• Gold
• Catechin
• Chitosan
• epigallocatechin gallate

Topics

• Animals
• Antineoplastic Agents (chemistry, therapeutic use, toxicity)
• Catechin (analogs & derivatives, chemistry, therapeutic use, toxicity)
• Cell Line, Tumor
• Chitosan (analogs & derivatives, chemistry)
• Drug Carriers (chemistry)
• Fucose (chemistry)
• Gold (chemistry)
• Helicobacter pylori (drug effects)
• Humans
• Kidney (pathology)
• Liver (pathology)
• Metal Nanoparticles (chemistry)
• Mice
• Microscopy, Electron, Transmission
• Nanocomposites (chemistry, therapeutic use, toxicity)
• Particle Size
• Spectroscopy, Fourier Transform Infrared
• Stomach Neoplasms (drug therapy, metabolism, pathology)
• Transplantation, Heterologous
• X-Ray Diffraction